孕妇Rh血型系统不规则抗体特异性分析与临床安全输血

Irregular antibody specificity analysis in Rh blood group systemand and clinical safety transfusion

目的:研究并探讨孕妇Rh血型系统不规则抗体筛查及特异性分布情况,为临床安全输血提供借鉴和帮助。方法:将2013年1月至2016年5月妇幼保健医院收治的2000例孕妇纳入作为研究对象,所有孕妇均采用Rh血型系统不规则抗体筛查试剂盒进行Rh血型系统不规则抗体筛查,统计其不规则抗体阳性检出情况和抗体特异性分布情况。结果:2000例孕妇中,共有69例孕妇检出Rh血型系统不规则抗体阳性,阳性检出率为3.45%,其中,有输血史的孕妇其不规则抗体阳性检出率明显高于无输血史孕妇(P<0.05);有妊娠史的孕妇其不规则抗体阳性检出率明显高于无妊娠史孕妇(P<0.05);有流产史的孕妇其不规则抗体阳性检出率明显高于无流产史孕妇(P<0.05)。结论:Rh血型不规则抗体阳性多分布于具有输血史、妊娠史、流产史的孕妇中,对孕妇进行Rh血型系统不规则抗体筛查和特异性鉴定,可保障孕妇临床输血安全。

Objective：To study and explore the irregular antibody screening and specific distribution of Rh blood group system in pregnant women,and to provide reference and help for clinical safe blood transfusion.Methods：From January 2013 to May2016,2000 pregnant women admitted to Maternal and Child Health Hospital in this stage were included in the study.All pregnant women were treated with Rh blood group system irregular antibody screening kit.Regular antibody screening,statistics of irregular antibody positive detection and antibody specific distribution.Results：Among the 2000 pregnant women,69 cases of pregnant women detected Rh blood group irregular antibody positive,the positive detection rate was 3.45%,of which the history of blood transfusion in pregnant women,the positive rate of irregular antibody was significantly higher than the history of non-blood transfusion（P〈0.05）.The positive rate of irregular antibody was significantly higher in women with miscarriage than that without pregnancy（P〈0.05）.The positive rate of irregular antibody was significantly higher in pregnant women Pregnant women with miscarriage（P〈0.05）.Conclusion：Rh blood group irregular antibody was mostly distributed in pregnant women with history of blood transfusion,history of pregnancy and abortion.The irregular antibody screening and specific identification of Rh blood group system in pregnant women could guarantee the clinical blood transfusion safety of pregnant women.