老年性痴呆52例血浆同型半胱氨酸水平的研究

A Study of the Relationship of Alzheimer′s Disease to Plasma Homocysteine Level with 52 Patients

目的:为探讨老年性痴呆(Alzheimer'sdisease,AD)的可能发病机制,研究血浆同型半胱氨酸(homocysteine,Hcy)水平与AD之间的关系。方法:采用毛细管电泳-紫外检测法测定52例AD患者及50名健康体检者的空腹血浆Hcy浓度,用独立样本t检验比较两组间血浆Hcy的差异。结果:AD患者空腹血浆Hcy浓度(16.57±4.49)μmol/L,显著高于对照组(11.96±3.87)μmol/L,t=5.49,P<0.001。结论:血浆Hcy轻度升高参与AD的发生发展。

Objective:To study the relationship between plasma homocysteine(Hcy) level and Alzheimer′s disease(AD) for investigating the pathogenesis of AD. Methods:The plasma Hcy level was determined in 52 cases of AD and 50 healthy controls by means of capillary electrophoresis ultraviolet detection.Results:The plasma Hcy level of the AD patient (16.57±4.49)μmol/L was markedly higher than that of the controls (11.96±3.87)μmol/L (t=5.49,P< 0.001).Conclusion: The elevated plasma Hcy level participates in the pathogenesis of AD.