乳腺癌彩色多普勒血流显像与微血管密度及乳腺癌预后的相关性研究

Correlation between color doppler flow imaging and microvessel density, and the Nottingham prognostic index in breast cancer patients

目的探讨乳腺癌彩色多普勒超声(CDFI)与微血管密度(MVD)及诺丁汉预后指数(NPI)的相关性。方法回顾性分析2011年9至2013年12月连云港市第一人民医院100例乳腺浸润性导管癌患者,采用CDFI检测乳腺癌血流信号,血流信号强度按照ADLER分为0~3级。免疫组化方法检测MVD评价乳腺癌的血管生成情况。术后病理评估肿瘤大小、淋巴结状态及组织学分级,诺丁汉预后指数(NPI)=病灶最大径(cm)×0.2+淋巴结分期(1~3)+组织学分级(1~3)。根据NPI评分(<3.4、3.4~5.4、>5.4)分为三个等级。统计分析CDFI分级和MVD及NPI的相关性。结果方差分析发现CDFI不同分级之间MVD数值差异有统计学意义(F=26.997,P<0.001);秩相关检验结果表明CDFI分级和NPI之间存在相关性(r=0.555,P<0.001)。随着CDFI逐级升高,MVD数目及NPI值逐渐增加。结论 CDFI与MVD及NPI显著相关,能够初步判断乳腺癌患者预后。

Objective To investigate the correlation between color doppler flow imaging （CDFI） and mierovessel density （MVD）, and the Nottingham prognostic index （NPI） in breast cancer patients. Methods One hundred patients with breast carcinoma, who had undergone CDFI and surgery, were involved in this retrospective study from September 2011 to December 2013 in the First Peoples＇ Hospital of Lianyungang. CDFI was divided into 4 levels： absent （grade 0）, minimal （grade 1）, moderate （grade 2）, and marked （grade 3）. The MVD was measured by immunohistochemical staining of their formalin-fixed paraffin-embedded tissue with monocloal antibody CD34. NPI was calculated as： NPI= 0.2 x tumor size （cm） ＋ grade （ I - m ） ＋ lymph node score （1-3）. Results Blood signal grades were positively correlated with MVD （F=26.997, P〈0.001） and NPI （Spearman r=0.555, P〈0.001）. With the increasing of CDFI, the number of MVD and value of NPI increased gradually. Conclusion CDFI may be useful as a prognostic indicator for patients with breast carcinoma.