低剂量依托泊苷维持治疗小细胞肺癌的临床效果

Clinical effect of low-dose Etoposide in the maintenance treatment of small cell lung cancer

目的探讨低剂量依托泊苷维持治疗小细胞肺癌的临床效果。方法回顾性分析2014年1月~2015年1月本院收治的80例局限期小细胞肺癌患者的临床资料,按照治疗方法的不同分为研究组与对照组,各40例。研究组采用低剂量依托泊苷胶囊维持治疗,对照组未行药物治疗。治疗后随访24个月,对比两组的治疗效果。结果研究组的无病生存时间明显长于对照组,差异有统计学意义(P<0.05);研究组随访12、24个月的生存率均高于对照组,差异有统计学意义(P<0.05);随访第12、18、24个月,研究组患者的生活质量评分均优于对照组,差异有统计学意义(P<0.05)。结论在小细胞肺癌治疗过程中,采用低剂量依托泊苷维持治疗的效果理想,能延长患者无病生存时间,提高24个月内的生存率,且能改善远期生活质量,值得进行深入研究和推广。

Objective To explore the clinical effect of low dose Etoposide in the maintenance treatment ot smart cen lung cancer.Methods The clinical data of 80 patients with limited-stage small cell lung cancer admitted into our hospital from January 2014 to January 2015 were retrospectively analyzed.According to the different therapeutic methods,all patients were divided into the research group and the control group,40 cases in each group.In the research group,low- dose Etoposide Capsule as a maintenance therapy was adopted,while in the control group,no medication was given.After 24-month follow-up visits,the therapeutic effect in the two groups was compared.Results The disease free survival time in the research group was greatly longer than that in the control group,with significant difference （P〈0.05）.In the research group,the survival rates in 12^th and 24^th months after follow-up visits were both higher than those in the control group,with significant differences （P〈0.05）.After 12,18,and 24-month follow-up visits,the scores of quality of life in the research group were all superior to those in the control group,with significant differences （p〈0.05）.Conclusion In the process of treating small cell lung cancer,application of low-dose Etoposide as a maintenance therapy can obtain a optimal effect by prolonging the disease free survival time,increasing the survival rate within 24 months,and improving long-term quality of life,which is worthy of further study and promotion.