补阳还五汤煎剂联合西药治疗气虚血瘀证急性脑梗塞的临床研究

Clinical Research of Buyang Huanwu Decoction Combined with Western Medicine in Treatment of Qi Deficiency and Blood Stasis Syndrome of Acute Cerebral Infarction

目的探讨补阳还五汤煎剂联合西药治疗气虚血瘀证急性脑梗塞的疗效。方法将我院收治的120例气虚血瘀证急性脑梗塞患者根据随机数字表法分为对照组与观察组各60例,对照组接受西医常规治疗,观察组则在西医常规治疗基础上再加用补阳还五汤治疗,对比分析两组患者的疗效。结果 (1)观察组疗效总有效率(95.00%)显著高于对照组(83.33%),有显著性差异(P<0.05)。(2)治疗前组间比较显示:两组患者血浆纤维蛋白原(Fbg)、红细胞压积(HCT)、全血低切粘度、血浆粘度相比差异无统计学意义(P>0.05);组内治疗前后比较显示:观察组与对照组患者血浆Fbg、HCT、全血低切粘度、血浆粘度治疗后均显著下降(P<0.05);治疗后组间比较显示:观察组血浆Fbg、HCT、全血低切粘度、血浆粘度显著低于对照组(P<0.05)。(3)治疗前组间比较显示:两组患者美国国立卫生院神经功能缺损评分(NIHSS)、FuglMeyer运动功能评定量表(FMA)评分、日常生活能力量表(ADL)评分相比差异无统计学意义(P>0.05);组内治疗前后比较显示:观察组与对照组患者NIHSS均显著下降(P<0.05),FMA评分、ADL评分均显著升高(P<0.05);治疗后组间比较显示:观察组NIHSS显著低于对照组(P<0.05),FMA评分、ADL评分显著高于对照组(P<0.05)。结论补阳还五汤煎剂联合西药可以改善气虚血瘀证急性脑梗塞患者的血液流变学指标,疗效显著,值得临床推广应用。

Objective To investigate the therapeutic effect ofBuyang Huanwu decoction combined with western medicine in treatment of qi deficiency and blood stasis syndrome of acute cerebral infarction. Methods 120 cases of patients with qi deficiency and blood stasis syndrome of acute cerebral infarction were randomly divided into control group and treatment group,60 cases in each group. Control group received routine treatment, observation group received Buyang Huanwu decoction on the basis of routine western medicine. Compare the effect of the two groups after treatment. Results （ 1 ）The total effective rate of observation group was 95%, significantly higher than 83.33% of control group （P〈0.05）.（2）The comparison between groups before treatmemt showed there was no significant difference in plasma fibrinogen （Fbg）, hematocrit （HCT）, whole blood low shear viscosity, and plasma viscosity between the two groups （P〉0.05）; the comparison between the groups before and after treatment showed the plasma Fbg, HCT, whole blood low shear viscosity and plasma viscosity of both groups decreased significantly after treatment （P〈0.05）;the comparison between the two groups after treatment showed the plasma Fbg, HCT, whole blood low shear viscosity and plasma viscosity of treatment group were significantly lower than those of control group （P〈0.05）. （ 3 ）The comparison between groups before treatment showed the scores of the National Institutes of Health Stroke Patients （NIHSS）, Fugl-Meyer motor function assessment scale （FMA）, daily life ability scale （ADL） in both groups were no statistically significant differences （P〉0.05）; the comparison between the groups before and after treatment showed NIHSS scores in both groups were significantly decreased （P〈0.05）, FMA scores and ADL scores were significantly increased （P〈0.05）; the comparison between the two groups after treatment showed the NIHSS score of treatment group was significantly lower than that of control group （P〈0.05）, FMA score, ADL score were significantly higher than those of control group （P〈0.05）. Conclusion Buyang Huanwu decoction combined with western medicine is effective in improving the index of blood rheology in patients with qi deficiency and blood stasis syndrome of acute cerebral infarction, is worthy of clinical application.