哈萨克族和汉族孕妇晚期妊娠可溶性血管内皮生长因子受体l与子痫前期的关系研究

sFlt-1 and Preeclampsia in Chinese Kazak and Han Pregnant Women During the Third Trimester of Pregnancy

目的探讨哈萨克族和汉族孕妇晚期妊娠可溶性血管内皮生长因子受体1(s Flt-1)与子痫前期(PE)的关系。方法选取2015年12月—2016年4月在新疆医科大学第一附属医院产科住院并分娩的孕妇110例,其中哈萨克族PE孕妇25例(哈萨克族PE组)、汉族PE孕妇25例(汉族PE组)、哈萨克族正常妊娠孕妇30例(哈萨克族正常妊娠组)、汉族正常妊娠孕妇30例(汉族正常妊娠组)。收集4组孕妇的临床资料,采用定量反转录聚合酶联反应(qRT-PCR)测定胎盘组织中的sFlt-1表达水平。结果哈萨克族PE组孕妇体质量高于汉族正常妊娠组,差异有统计学意义(P<0.05);哈萨克族PE组、汉族PE组孕妇收缩压、舒张压高于哈萨克族正常妊娠组、汉族正常妊娠组,孕周短于哈萨克族正常妊娠期、汉族正常妊娠期,新生儿体质量低于哈萨克族正常妊娠组、汉族正常妊娠组,差异有统计学意义(P<0.05)。汉族PE组、汉族正常妊娠组孕妇血红蛋白高于哈萨克族PE组、哈萨克族正常妊娠组,哈萨克族PE组、汉族PE组孕妇肌酐高于哈萨克族正常妊娠组、汉族正常妊娠组,差异有统计学意义(P<0.05)。汉族PE组孕妇sFlt-1表达水平高于哈萨克族PE组、哈萨克族正常妊娠组、汉族正常妊娠组,哈萨克族PE组孕妇sFlt-1表达水平高于哈萨克族正常妊娠组、汉族正常妊娠组,差异有统计学意义(P<0.05);而哈萨克族正常妊娠组、汉族正常妊娠组孕妇sFlt-1表达水平比较,差异无统计学意义(P>0.05)。哈萨克族重度PE、汉族重度PE、哈萨克族轻度PE、汉族轻度PE孕妇sFlt-1表达水平比较,差异无统计学意义(P>0.05)。结论晚期妊娠s Flt-1可能参与了PE的发生、发展,可作为预测PE发生、发展的血液学指标,但不能作为预测PE患者病情严重程度的指标。

Objective To explore the relationship between the soluble vascular endothelial growth factor receptor 1（ s Flt-1） and preeclampsia（ PE） in Chinese Kazakh and Han pregnant women in the third trimester of pregnancy. Methods We enrolled 110 pregnant women who delivered in Obstetrics Department, The First Affiliated Hospital of Xinjiang Medical University between December 2015 and April 2016 and divided them into Chinese Kazakh pregnant women with PE（ Kazakh PE group,n = 25）,Chinese Han pregnant women with PE（ Han PE group,n = 25）,normal Chinese Kazakh pregnant women（ normal Kazakh group,n = 30） and normal Chinese Han pregnant women（ normal Han group,n = 30）. We obtained the clinical data of all the participants. The level of s Flt-1 in the placental tissues was measured by qRT-PCR. Results The average weight of the Kazakh PE group was higher than that of normal Han group（ P〈0. 05）. The average levels of systolic and diastolic blood pressure were higher in the PE groups than in the normal groups（ P〈0. 05）. Both PE groups had shorter gestational weeks than the normal groups（ P〈0. 05）. The average neonates delivered by PE groups demonstrated lower birth weight compared with those delivered by the normal groups（ P〈0. 05）. The average hemoglobin levels were found to be higher in Han groups than in the Kazakh groups（ P〈0. 05）. PE groups presented higher average creatinine levels than the normal groups（ P〈0. 05）. The expression level of s Flt-1 in the Han PE group was identified to be the highest（ P〈0. 05）. Kazak PE group showed higher expression level of s Flt-1than the normal groups（ P〈0. 05）. The expression level of s Flt-1 did not differ significantly between normal Kazak group and normal Han group（ P〈0. 05）. The Kazak severe PE subgroup,Kazak mild PE subgroup,Han severe PE subgroup,and Han mild PE subgroup showed similar expressional levels of s Flt-1（ P〈0. 05）.Conclusion s Flt-1,a haematological marker,may be involved in the development of preeclampsia during the third trimester of pregnancy. PE can be identified by the expression level of s Flt-1,while the severity of PE can not.