摘要
目的探讨血清免疫固定电泳(immunofixtion electrophpresis,IFE)联合轻链检测在多发性骨髓瘤(multiple myeloma,MM)诊断中的意义。方法收集2016年3月至2016年7月在南京医科大学第一附属医院就诊的MM患者120例以及同期健康体检者30例,对MM患者血清进行IFE和轻链定量检测,各组间的比较采用t检验。结果 120例MM患者有115例IFE检出M带,检出率为95.83%,其中以IgG型最多(61.67%),IgA型(26.66%)和轻链型(2.50%)次之,IgM型(1.67%)较少见。轻链检测结果显示,κ/λ比值在MM的各种免疫分型中差异均有统计学意义(P<0.05)。结论 IFE和轻链检测对MM的诊疗具有重要临床应用价值。
Objective To evaluate the diagnostic significance of immunofixtion electrophpresis （IFE） and light chain analysis in multiple myeloma（MM）. Methods We selected 120 MM patients as study group and 30 healthy subjects as control group from the First Affiliated Hospital of Nanjing Medical University. IFE and light chain test were performed on serum samples of these patients. T test was used for the statistical analysis. Results M protein was positive in 115 cases （95.83%） among 120 MM patients by using IFE. IgG were the most type of the M protein （61.67%）, and IgA type （26.66%）, light chain （2.50%） and IgM type （1.67%）. Light chain test showed that the ratio of κ/λ was significantly abnormal in different types of MM （P〈0.05）. Conclusion IFE and light chain test have great clinical value in the diagnosis and treatment of MM.
出处
《标记免疫分析与临床》
CAS
2017年第10期1088-1090,共3页
Labeled Immunoassays and Clinical Medicine
基金
江苏省实验诊断学重点实验室基金(XK 201114)
