质子泵抑制剂和重度AECOPD患者的医院获得性肺炎之间关系

Proton pump Inhibitors and the Relationship between Severe AECOPD Patients with Hospital Acquired Pneumonia

目的探讨应用质子泵抑制剂(PPI)是否是重度慢性阻塞性肺病急性加重期(AECOPD)患者发生医院获得性肺炎(HAP)的危险因素。方法收集我科2015年6月1日至2016年1月31日重度AECOPD患者198例,其中使用PPI患者96例,未使用PPI患者102例,使用Logistic回归分析PPI与HAP发生率的关系。结果使用PPI组HAP发生率较未使用PPI组高,特别是超过使用PPI药物7天患者。在不同多变量Logistic回归模型中,用APACHEII评分校正后,使用PPI及使用PPI的天数示重度ACOPD患者HAP的危险因素。结论长时间使用PPI可以增加重度AECOPD患者HAP发生率。

Objective This study aimed to explore risk factors about the application of proton pump inhibitors（PPI）in severe AECOPD patients with hospital acquired pneumonia（HAP）.Methods A total of 198 patients with severe AECOPD were collected from June 1,2015 to January 31,2016,including 96 patients with PPI and 102 patients without PPI.The incidence of PPI and HAP was analyzed by Logistic regression analysis.Results The incidence of HAP in group PPI was higher than that in the unused PPI group,especially for patients 7 days after the use of PPI drugs.In the regression model of different multivariate Logistic,corrected by the APACHEII score,days of using PPI and PPI was ACOPD HAP in patients with severe risk factors.Conclusion Prolonged use of PPI can increase the incidence of HAP in patients with severe AECOPD.