5-取代-4-羟基苯甲氨基-3-巯基-1,2,4-三唑的无溶剂合成

Synthesis of 5-substituted-3-hydrosulfuryl-4-hydroxybenzylamino-1,2,4-triazole under solvent-free conditions

在无溶剂条件下,由羟基苯甲醛,5-取代-3-巯基-4-氨基-1,2,4-三唑,对甲苯磺酸经过室温研磨合成了5-取代-4-羟基苯亚甲氨基-3-巯基-1,2,4-三唑,此化合物再经硼氢化钠还原得到5-取代-4-羟基苯甲氨基-3-巯基-1,2,4-三唑衍生物.其结构分别用IR,NMR和MS进行了表征.此方法具有反应条件温和,操作简单,产率高等优点,是一种有效合成5-取代-4-羟基苯甲氨基-3-巯基-1,2,4-三唑衍生物的新方法.

5-substituted-3-hydrosulfuryl-4-hydroxybenzmethyleneamino- 1,2,4-triazole were synthesized by reaction of 5 - substituted - 3 - hydrosulfuryl - 4 - amino - 1,2,4 - triazole and hydroxybenzaldehyde in the presence of p-toluenesulfonic acid under solvent-free conditions by grinding at room temperature, and then, the synthesized compounds were reduced to 5-substituted-3-hydrosulfuryl-4-hydroxybenzylamino-1,2,4-triazole , The structures of the products were characterized by IR, NMR and MS. The procedure offers several advantages including milder reaction conditions, easier work- up and higher yields, It is a novel synthesis method of 5- substituted- 3-hydrosulfury1-4 -arylmethylamino - 1,2,4-triazole.