实验性脑出血胃局部胃泌素的变化及其意义

The changes of the gastrin at gastric mucosa in experimental intracerebral hemorrhage

目的 探讨急性脑出血时胃泌素的变化及其在脑-胃肠综合征中的作用。方法 采用胶原酶加肝素联合注射建立脑出血动物模型,用放射免疫法测定胃粘膜局部胃泌素含量。结果 脑出血后胃粘膜局部胃泌素含量明显升高,明显高于对照组,出血后24h达峰值。结论 急性脑出血时,胃泌素分泌增多,活性增强,通过作用于胃粘膜G细胞促进胃酸分泌以及使胃肠运动紊乱,加重脑-胃肠综合征的发生、发展。

Objective To investigate the changes of the gastrin during the acute cerebral vascular diseases and determine the effect of the gastrin on cerebro-gastrointeral syndrom. Methods Rat intracerebral hemorrhage model was produced with infusing collagenase and heparin. The content of the gastrin was determined by radioim-munoassay in gastric mucosa. Results The gastrin of gastric mucosa increased significantly after intracerebral hemorrhage and was higher comparaed with the control group. The gastrin of gastric mucosa reached the peak at 24h after intracerebral hemorrhage. Conclusion Both the secretion and the activity of the gastrin increase after in-tracerebral hemorrhage. The gastrin is aggravated the cerebro-gastrointeral syndrome, which stimulates the gas-tric mucosa G cell to secrete the gastric acid and induces the disorder of the gastrointestinal movement.