氧化应激与胰腺癌的关系

Association between oxidative stress and pancreatic cancer

胰腺癌早期症状不明显,发现时通常已进展至中晚期。目前晚期胰腺癌主要以化疗为主,但化疗对胰腺癌的有效率较低,给治疗带来了极大的挑战。氧化应激引起的活性氧可损伤DNA、蛋白质和脂质,并产生可改变肿瘤生物学行为的有毒和致突变的代谢产物,使该肿瘤转化为恶性表型。抗氧化剂具有抗癌的保护性作用,为抗氧化应激治疗胰腺癌的药物设计提供了基础。简述氧化应激与胰腺癌相关的分子通路研究进展,以便进一步探索靶向活性氧治疗胰腺癌的新方法。

Pancreatic cancer（ PC） is often asymptomatic in the early stage and most patients have progressed to the advance stage at the time of diagnosis. At present,chemotherapy is mainly used in patients with advanced PC,but PC patients have poor response to chemotherapy,which brings great challenges to the treatment of PC. Oxidative stress-induced reactive oxygen species（ ROS） can cause damages in DNA,proteins,and lipids and produce the toxic and mutagenic metabolites that alter the biological behavior of tumor and transform the tumor into a malignant phenotype. Antioxidants have an antitumor effect and provide a basis for the design of anti-oxidative stress drugs for the treatment of PC. This article summarizes the research advances in the molecular pathways associated with oxidative stress and PC,in order to explore new ROS-targeted methods for the treatment of PC.