3,4,5-三甲氧基查尔酮的结构修饰与抗肿瘤活性研究进展

Study Advances of Structural Modification and Antitumor Activities of 3,4,5-Trimethoxy Chalcones

查尔酮是一类广泛存在于自然界中的黄酮类化合物,具有抗肿瘤、抗菌、抗病毒等多种生物活性。近年来,通过对查尔酮进行大量的结构修饰,发现3,4,5-三甲氧基查尔酮是一类具有良好的抗肿瘤活性的新型查尔酮。本文主要对3,4,5-三甲氧基查尔酮的结构修饰及抗肿瘤作用的研究进展进行综述,旨在为今后开发3,4,5-三甲氧基查尔酮类抗肿瘤药物提供依据。

Chalcone was a kind of natural polyphenol widely found in natural plants and had various biological activities included anti-tumor, anti-bacterial, antiviral activities. Recently, a great deal of structural modifications on chalcone have found 3,4,5-trimethoxy chalcones was a new kind of chalcone with good anti-tumor activity. In this paper, the research advances of structural modification of 3,4,5-trimethoxy chalcones, as well as anti-canceractivities were reviewed, and those would provided assistances for the future development of 3,4,5-trimethoxy chalcone drugswith high and specific anti-tumor activity.