胸壁硬化性纤维母细胞瘤临床病理特征研究

Clinicopathologic features of sclerotic fibroblastoma on chest wall

目的探讨硬化性纤维母细胞瘤(DF)的临床病理特点。方法观察1例胸壁DF的组织学及免疫表型并复习相关文献。结果患者男,56岁,发现胸壁皮肤结节5年,长大1年。镜下肿瘤细胞稍显稀少,以中等大小或大的梭形细胞为主,间以少量星形细胞,胞浆略嗜碱性,胞核椭圆形或胖梭形。间质以胶原纤维为主,局灶区域黏液样变性。免疫组化:肿瘤细胞弥漫性阳性表达波形蛋白,部分肿瘤细胞表达抗平滑肌抗体,不表达角蛋白、结蛋白、抗肌内膜抗体、S-100、分化簇抗原3434、增殖指数(阳性细胞数1%)。结论 DF是一种罕见的良性软组织病变,手术切除后极少复发和转移。

Objective To explore the clinicopathologic features of sclerotic desmoplastic fibroblastoma（DF）.Methods The histological and immunological phenotype in 1case of DF was observed and the related literatures were reviewed.Results A 56-yearold man presented with 5years history of a nodular on the chest wall region with swelling for 1year.Macroscopically,the lesion was composed of spindle cells or stellate shaped cells with basophilous cytoplasm and oval nucleus,accompanied by abundant collagenous stroma.The mesenchyma was dominated by collagenous fibers.The local region showed the mucoid degeneration.The immunohistochemistry：the tumor cells diffusely expressed Vimentin,some tumor cells expressed SMA,while CK,Desmin,EMA,S-100,CD34 and Ki67（positive cells number 1%）were not expressed.Conclusion DF is a rare benign soft tissue lesion and is rarely recurred and has little recurrence and metastasis after operative resection.