Hp感染状况与儿童消化道慢性疾病的关系

Relationship Between Hp Infection and Childhood Chronic Diseases

目的探讨Hp感染状况与儿童消化道慢性疾病的关系。方法选择2015年1月—2016年12月来我院消化内科门诊和病房就诊行13C呼气检查的患儿3 753例,搜集患者的临床资料,行13C尿素呼气试验检查,了解不同性别幽门螺杆菌感染情况,不同年龄学生幽门螺杆菌感染情况,不同疾病表现组幽门螺杆菌感染情况。结果该人群中Hp总感染率为46.3%(1 737/3 753),其中男生感染率为47.4%(1 059/2 234),女生为44.6%(678/1 519)。Hp感染在男女生之间差异无统计学意义;不同年龄组Hp感染率不同,其感染率分别为29.5%(240/813)、38.6%(767/1 987)、45.1%(430/953),经Spearman相关分析,年龄与感染率呈弱相关;本次研究对象按就诊的主要诊断分为慢性腹痛组、便秘组、消化不良组、贫血组、其他组,不同疾病表现组Hp感染率不同,其感染率分别为49.8%(1 113/2 235)、45.6%(312/685)、42.0%(183/436)、30.6%(36/117)、33.2%(93/280)。结论目前儿童Hp感染率较高,随着年龄的增长感染率越高,不同疾病表现组感染率有所不同。

Objective To investigate the relationship between Hp infection and chronic diseases in children with digestive tract. Methods 3 753 cases of children who underwent 13C breath examination in digestive medicine outpatient and ward of our hospital from January 2015 to December 2016 were enroll in the study, the patient＇s clinical data was collected, 13C urea breath test was used to understand the different helicobacter pylori infection in different genders, ages, and different disease manifestations. Results The total infection rate of Hp was 46.3% （1 737/3 753）, among which the infection rate was 47.4% （1 059/2 234） and 44.6% （678/1 519）. The infection rate of Hp infection was 29.5% （240/813）, 38.6% （767/1 987）, 45.1% （430/953）. The infection rate of Hp infection was different between male and female. According to Spearman correlation analysis, age and infection rate were weakly correlated. The subjects were divided into chronic abdominal pain group, constipation group, indigestion group, anemia group, other groups and different disease groups. The Hp infection rate was different, the infection rates were 49.8% （1 113/2 235）, 45.6% （312/685）, 42.0% （183/436）, 30.6% （36/117） and 33.2% （93/280）. Conclusion The prevalence of HP infection is high in children, and the infection rate is different with the increase of age. The infection rate of different disease groups is different.