大剂量环磷酰胺与甲基泼尼龙冲击治疗过敏性紫癜性肾炎的效果分析

Effect of High Dose Cyclophosphamide and Methylprednisolone on the Treatment of Henoch-schonlein Purpura Nephritis

目的探讨大剂量环磷酰胺与甲基泼尼龙冲击治疗过敏性紫癜性肾炎的效果。方法选择2015年5月—2017年1月在我院接受治疗的过敏性紫癜性肾炎患者共74例,将其随机分为对照组和治疗组,每组37例。对照组采用甲基泼尼龙冲击治疗,治疗组采用甲基泼尼龙的基础上联合大剂量环磷酰胺进行冲击治疗,观察两组患者的临床疗效。结果在本次治疗中,对照组总有效率为75.68%,治疗组总有效率为94.59%,差异有统计学意义(P<0.05)。治疗后,治疗组患者尿蛋白水平低于对照组,改善效果差异具有统计学意义(P<0.05)。对照组总不良反应发生率为27.03%,治疗组总不良反应发生率为5.41%,差异具有统计学意义(P<0.05)。结论对过敏性紫癜性肾炎患者的治疗中,采用大剂量环磷酰胺联合甲基泼尼龙冲击治疗有着良好的效果,能够改善患者临床症状。

Objective To investigate the effect of high dose cyclophosphamide and methylprednisolone in the treatment of henoch-schonlein purpura nephritis. Methods A total of 74 patients with henoch-schonlein purpura nephritis who were treated in our hospital from May 2015 to January 2017 were randomly divided into control group and treatment group. The control group was treated with methylprednisolone, and the treatment group was treated with methylprednisolone on the basis of high dose cyclophosphamide, the clinical effect of the two groups were observed. Results In this treatment, the total effective rate of the control group was 75.68%, the total effective rate of the treatment group was 94.59%, there was significant difference （P 〈 0.05）. After treatment, the level of urinary protein in the treatment group was signifcantly lower than that in the control group, the improvement effect was more obvious, the difference was statistically significant （P 〈 0.05）. The incidence of total adverse reactions in the control group was 27.03%. The incidence of total adverse reactions in the treatment group was 5.41%, the difference was statistically significant （P 〈 0.05）. Conclusion The treatment of patients with henoch-schonlein purpura nephritis with high-dose cyclophosphamide combined with methylprednisolone has a good effect, can significantly improve the clinical symptoms of patients.