多索茶碱治疗60例支气管哮喘患者的肺功能改善及预后分析

Lung function improvementsand prognosis analysis of 60 patients with bronchial asthma after Doxofylline treatment

目的:观察多索茶碱治疗支气管哮喘患者的肺功能改善及预后分析。方法:选择支气管哮喘患者60例。随机分成观察组和对照组,每组30例。在常规治疗的基础上,观察组采用多索茶碱滴注治疗,对照组采用氨茶碱滴注治疗,治疗周期为1周。然后比较两组疗效、肺功能指标的变化和不良反应等。结果:两组患者治疗前后的FVC、FEV1、FEV1/FVC及PEF指标明显改善;观察组治疗后肺功能显著优于对照组(P<0.01);观察组的治疗总有效率为90.0%,明显高于对照组的66.67%;差异有统计学意义(P<0.05)。治疗后不良反应发生率分别是6.67%、33.33%,比较差异有统计学意义(P<0.05)。结论:多索茶碱治疗支气管哮喘有明显疗效,可以明显改善患者的肺功能,安全性较高。

Objective： To explore lung function improvements and perform a prognosis analysis for patients with bronchial asthma after the Doxofylline treatment.Methods： 60 patients with bronchial asthma were selected andrandomly divided into observation group and control group,30 cases in each group.On the basis of the conventional treatment,the observation group used the Doxofylline drip treatment,while the control group was treated with Aminophylline drip.The treatment lasted for a week.Then,the treatment effects,the changes of lung function indexes,adverse reactionsand the like of the two groups were compared.Results： After the treatment,the FVC,FEV1,FEV1/FVC and PEF of the two groups were improved significantly （P0.01）.The lung function of the observation group was significantly better than that of the control group （P0.01）.The total effective rates of observation group and control group were 90.0% and 66.67%,respectively,and the difference was statistically significant （P〈 0.05）.The adverse reaction rates of observation group and control group were 6.67% and 33.33%,respectively,and the difference was not statistically significant （P〈 0.05）.Conclusions： Doxofylline in the treatment of bronchial asthma has apparent curative effects,can significantly improve the patients＇ pulmonary function,and is safer.