加味白术汤联合培菲康对肺炎继发腹泻患儿血清GAS、MOT、SS的影响

Effects of Jiawei Baizhu decoction combined with peifukang on serum GAS,MOT and SS in children with secondary diarrhea

目的:探讨加味白术汤联合培菲康对肺炎继发腹泻患儿血清胃泌素(GAS)、血浆胃动素(MOT)以及生长抑素(SS)的影响。方法:将80例肺炎继发腹泻患儿按照奇偶数字法均分为对照组与观察组,两组患儿均对症给予抗生素治疗,对照组在此基础上联合培菲康胶囊治疗,观察组在对照组的基础上联合加味白术汤进行治疗。比较两组临床疗效、治疗前后患儿GAS、MOT、SS水平及生活质量的变化情况。结果:经治疗,观察组临床总有效率为92.50%,显著高于对照组的80.00%(P<0.05);与治疗前相比,治疗后两组患儿机体GAS、MOT水平均显著降低(P<0.05),SS水平均显著升高(P<0.05),且观察组患儿治疗前后上述三种指标水平变化程度均显著优于对照组(P<0.05);两组患儿治疗后CIVIQ量表各维度及总得分均分别显著高于治疗前(P均<0.05)。结论:加味白术汤配联合培菲康治疗小儿肺炎继发腹泻疗效确切,其发挥作用的机理可能与改善胃肠激素相关。

Objective： To investigate the effects of Jiawei Baizhu decoction combined with GAS, MOT and SS in children with secondary diarrhea influences. Methods： Eighty children with recurrent diarrhea were divided into control group and observation group according to odd and even digital method. The two groups of children were symptomatically treated with antibiotics. On the basis of the control group treatment group the observation group in the control group based on the combination of Jiawei Baizhu decoction for treatment. The changes of GAS, MOT, SS level and quality of life were compared between the two groups before and after treatment. Results ： After treatment, the total effective rate was 92. 50% in the observation group, which was significantly higher than that in the control group （P 〈0. 05）. The levels of GAS and MOT in the two groups were significantly lower than those in the control group （P〈0 . 05） , and the changes of the three indexes were significant （P〈0 . 05）. After treatment of two groups of children, the dimensions and total score of the CIVIQ scale were significantly higher than those in the treatment （P 〈 0. 05）,respectively. Conclusion： Jiawei Baizhu decoction combined with Peifukang is effective in the treatment of secondary diarrhea in children with pneumonia. The mechanism of action may be related to the improvement of gastrointestinal hormones and should be popularized in clinical practice.