AMPK/SIRT1/NF-κB通路在糖尿病心肌病中的作用

Role of AMPK/SIRT1/NF-κB signaling pathway in diabetic cardiomyopathy

糖尿病心肌病是糖尿病重要并发症之一,其发病机制涉及糖脂代谢紊乱、胰岛素抵抗、氧化应激、心肌细胞凋亡等诸多因素。腺苷酸活化蛋白激酶(AMPK)是机体能量的感受器,可以调节机体代谢状态并激活下游众多分子。SIRT1是一个去乙酰化酶,参与调节由能量限制引发的长寿作用。核转录因子-κB(NF-κB)参与多种炎症因子转录调控并发挥关键作用。研究表明这三者之间存在着相互调控关系,可形成AMPK/SIRT1/NF-κB通路对下游分子产生级联反应。该文主要关注该通路在糖尿病心肌病中的作用。

Diabetic cardiomyopathy is one of the vital complications of diabetes mellitus. The underlying pathogenesis is involved with glycolipid metabolic disorder,insulin resistance,oxidative stress,myocardial cell apoptosis and alternative multiple factors. As a cellular energy sensor,adenosine 5'-monophosphate-activated protein kinase( AMPK) can regulate the metabolic status and activate multiple molecules in the downstream signaling pathway. SIRT1 is nicotinamide adenine dinucleotide-dependent histone deacetylase,which participates in the regulation of longevity effect induced by calorie restriction. NF-κB plays a pivotal role in regulating the transcription of multiple inflammatory cytokines. These three cytokines exert a mutually regulatory effect,which lead to the cascade reaction of the molecules in the downstream AMPK/SIRT1/NF-κB signaling pathway.