复方生精汤治疗男性不育及对精子质量和激素水平的影响

Effects of compound Shengjing decoction on the sperm quality and hormone level in infertile males

目的:研究复方生精汤治疗男性不育及对精子质量和激素水平的影响,初步阐明本方剂的作用机制。方法:将198例男性不育患者,随机分为复方生精汤治疗组100例和六味地黄丸对照组98例,在治疗前及治疗3个月后,利用计算机辅助精子分析系统(CASA)分析精子质量、采用电化学发光免疫分析法检测血清性激素、采用改良的间苯二酚显色法检测精浆中果糖含量,并重点观察治疗总效果。结果:两组临床总有效率分别为84.00%和63.26%,差异有统计学意义(P<0.01)。治疗组治疗后精浆中果糖含量、卵泡刺激素、促黄体生成激素、睾酮升高,而雌二醇明显下降,治疗前后两组指标均有显著性差异(P<0.05)。结论:复方生精汤治疗男性少弱精子症等所致的男性不育有显著效果,其作用机制可能与其促进精囊腺分泌果糖,提高精浆果糖含量,同时促进生殖系统附属其他相关性腺分泌功能,调节血清中激素水平,为精子生产成熟等全过程提供物质基础有关。

Objective：To explore the therapeutic effects of compound Shengjing decoction on the sperm quality and hormone level in infertile males.Methods：A total of 198 infertile patients were randomly assigned into treatment group（n=100,took compound Shengjing decoction）and control group（n=98,took Liuweidihuang pills）.After 3 months of treatment,sperm activity,sperm motility,hormone level,and fructose of seminal plasma were analyzed by CASA,ECLI and improved resorcinol chromogenic method.Results ：The total effective rate was 84.00% and 63.26%in the treatment group and control group,with significant difference（P0.01）.The fructose,follicle-stimulating hormone（FSH）,testosterone（Tes）,and luteinizing hormone（LH）levels increased in the treatment group,while estradiol（E_2）decreased.There were significant differences between the treatment and control groups（P0.05）.Conclusions：Compound Shengjing decoction is effective in the treatment of male oligoasthenozoospermic and asthenozoospermatic patients.The possible mechanism is that it can promote the seminal vesicle gland secretion of fructose,increase the level of seminal plasma and facilitate secretion of other related gonads attached to the reproductive system.It can regulate hormones such as FSH,Tes,LH and E2,providing substances for the process of spermatogenesis and maturation.