宣上畅中渗下法治疗痰湿质慢性支气管炎临床观察

Clinical observation of Xuanshang-changzhong-shenxia therapy on chronic bronchitis of phlegm-dampness constitution

目的观察宣上畅中渗下法治疗痰湿质慢性支气管炎的临床疗效。方法将60例痰湿质慢性支气管炎患者随机分为2组,对照组30例予常规西药治疗,治疗组30例在对照组治疗基础上应用宣上畅中渗下法治疗,2组均14 d为1个疗程,治疗1个疗程,疗程结束后随访3个月。观察2组治疗前后血常规[白细胞计数(WBC)、中性粒细胞(N)]、血糖[空腹血糖(FPG)、餐后2 h血糖(2 hPG)]、肝功能[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)]、血脂[甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]指标变化,比较2组治疗前后痰湿体质评分,评价疗效。结果 2组慢性支气管炎合并2型糖尿病患者治疗后、随访3个月时WBC、N、FPG及2 hPG均较本组治疗前降低(P<0.05);治疗组治疗后、随访3个月时FPG及2 hPG均低于对照组同期(P<0.05)。2组慢性支气管炎未合并2型糖尿病患者治疗后、随访3个月时WBC、N、FPG及2 hPG均较本组治疗前降低(P<0.05);2组治疗后、随访3个月时WBC、N、FPG及2 hPG比较差异均无统计学意义(P>0.05)。2组治疗前后肝功能、血脂指标比较差异均无统计学意义(P>0.05)。2组治疗后、随访3个月时痰湿质评分均较本组治疗前降低(P<0.05),且治疗组治疗后、随访3个月时痰湿质评分低于对照组治疗后、随访时(P<0.05)。治疗组复发率6.67%、总有效率93.33%,对照组复发率13.30%、总有效率83.33%,2组复发率、总有效率比较差异均有统计学意义(P<0.05),治疗组疗效优于对照组。结论宣上畅中渗下法能有效改善慢性支气管炎患者的痰湿体质偏向,达到减缓疾病的进展和复发目的,提高患者生活质量。

Objective To observe the clinical effects of Xuanshang-changzhong-shenxia therapy on the treatment of chronic bronchitis of phlegm-dampness constitution. Methods 60 chronic bronchitis patients with phlegm-dampness constitution were randomly divided into two groups. 30 cases in the control group were treated by routine western medicine,and 30 cases in the treatment group were treated by Xuanshang-changzhong-shenxia therapy on the basis of the control group. The treatment course was 14 d in two groups and 3 months follow-up after treatment. The blood routine including white blood cell count（ WBC） and neutrophil（ N）,blood glucose including fasting plasma glucose（ FPG） and 2 h postprandial glucose（ 2 hPG）,liver function including alanine aminotransferase（ ALT） and aspartate aminotransferase（ AST）,blood lipid including triglyceride（ TG） and low-density lipoprotein cholesterol（ LDL-C） before and after treatment were observed in two groups. The scores of phlegm-dampness constitution before and after treatment were compared in two groups,and the effects were evaluated. Results The WBC,N,FPG and 2 hPG of chronic bronchitis patients complicated with type 2 diabetes after treatment and 3 months follow-up were reduced in two groups（ P 〈 0. 05）.The FPG and 2 hPG after treatment 3 months and follow-up in treatment group were lower than that in control group at the same period（ P 〈 0. 05）. The WBC,N,FPG and 2 hPG of chronic bronchitis patients not complicated with type2 diabetes after treatment and 3 months follow-up were reduced in two groups（ P 〈 0. 05）. There was no statistical difference on the WBC,N,FPG and 2 hPG after treatment 3 months and follow-up betwenn the two group（ P 0. 05）. There was no statistical difference on the indexes of liver function and blood lipid before and after treatment in two groups（ P 〈 0. 05）. The scores of phlegm-dampness constitution after treatment and 3 months follow-up were reduced in two groups（ P 〈 0. 05）,and which in treatment group was lower than that in control group at the same period（ P 〈 0. 05）. There were statistical differences on the recurrence rate and the total effective rate between the treatment group（ 6. 67%,93. 33%） and the control group（ 13. 30%,83. 33%,P 〈 0. 05）,and the curative effects in treatment group was superior to that in control group. Conclusion Xuanshang-changzhong-shenxia therapy can effectively improve phlegm-dampness constitution bias of the chronic bronchitis patients,thus achieve the purposes that slow down the progress of the disease and relapse purposes,improve the patient＇s quality of life.