摘要
目的探讨补肾活血通络方加减治疗原发性膝骨性关节炎急性发作临床效果,以期丰富治疗方法,提高疗效。方法将94例原发性膝骨性关节炎急性发作随机分成2组,对照组47例,予常规西药治疗,观察组47例,加用补肾活血通络方,观察治疗后安全性指标、血清学指标和相关评分改善情况。结果 2组治疗后在疼痛、僵硬、日常生活能力、压痛、肿胀、关节活动度上均显著低于治疗前,治疗前后比较差异具有统计学意义(P〈0.05),治疗后观察组在以上六个指标上显著优于对照组(P〈0.05)。2组治疗后在MMP-3、CRP、IL-1、TNF-α显著低于治疗前,治疗前后比较差异具有统计学意义(P〈0.05),治疗后观察组以上指标显著优于对照组(P〈0.05)。结论补肾活血通络方能改善原发性膝骨性关节炎急性发作临床症状,降低炎症反应,且安全性高。
Objective To investigate the clinical effect of Bushen Huoxue Tongluo Recipe in the treatment of acute attack of primary knee osteoarthritis,so as to enrich the treatment method and improve the curative effect.Methods 94 cases of primary knee osteoarthritis acute attack were randomly divided into 2 groups,47 cases in the control group were treated with conventional western medicine treatment,the observation group of 47 cases,treated with Bushen Huoxue Tongluo Decoction,were observed after treatment in the improvement of the safety index,serum indexes and related score.Results The two groups at the end of the pain,stiffness,ADL,tenderness,swelling,joint activities are significantly lower than before treatment,after treatment were significantly different(P〈0.05) at the end of treatment,the observation group in the above six indicators were significantly better than the control group(P〈0.05);group MMP-3,two at the end of treatment CRP,IL-1,TNF-were significantly lower than before treatment,after treatment were significantly different(P〈0.05) at the end of treatment observation group above index was significantly better than the control group(P〈0.05).Conclusion:Bushen Huoxue Tongluo Decoction can improve the primary acute exacerbation of knee osteoarthritis clinical symptoms,reduce inflammation,and high safety.
出处
《中国生化药物杂志》
CAS
2017年第10期66-68,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
补肾活血通络方
原发性膝骨性关节炎
急性发作
疗效
Bushen Huoxue Tongluo recipe
primary osteoarthritis of the knee
acute attack
curative effect