国产艾司奥美拉唑针剂治疗消化性溃疡出血的疗效及安全性观察

Efficacy and safety of domestic esomeprazole in the treatment of peptic ulcer bleeding

目的探讨国产艾司奥美拉唑针剂治疗消化性溃疡出血的安全性及对溃疡愈合率的影响。方法选取浙江萧山医院2016年1月～2016年12月收治的98例消化性溃疡出血患者,采用随机数表法将患者平均分为观察组和对照组。2组患者均接受相同的常规治疗,在此基础上观察组采用国产艾司奥美拉唑针剂,对照组使用原研艾司奥美拉唑针剂,比较2组患者临床疗效及安全性。结果观察组和对照组患者在治疗有效率、出血情况以及不良反应总发生率的比较差异无统计学意义;但观察组患者成本效果比例显著低于对照组患者（P〈0.05）。结论治疗消化性溃疡出血,国产和原研艾司奥美拉唑针剂治疗均可获得较令人满意的临床疗效,相比较而言,国产艾司奥美拉唑针剂费用更低。

Objective To analyze the safety and efficacy of domestic esomeprazole injection in treating peptic ulcer bleeding.Methods A total of 98 patients with peptic ulcer bleeding were enrolled in Zhejiang Xiaoshan hospital from January 2016 to December 2016 were divided into the observation group and the control group by random number table.Both groups were given the same routine treatment,the observation group was given domestic esomeprazole injection on the basis treatment,the control group was given imported eschenopramine injection,clinical efficacy and safety of two groups were compared.Results There was no significant difference in the effective rate of treatment,the total efficacy and adverse reactions between two groups,but the cost in the observation group was significantly lower than that of the control group（P〈0.05）.Conclusion For the treatment of peptic ulcer bleeding,both of domestic and imported eschenopramine injection treatment could be received more satisfactory clinical efficacy,but the cost of domestic esomeprazole injection is lower than that of imported esomeprazole..