唑来膦酸治疗高龄骨质疏松性不稳定转子间骨折患者的临床效果观察

Clinical efficacy of zoledronic acid in the treatment of osteoporotic unstable intertrochanteric fracture in the elderly

目的分析唑来膦酸治疗高龄骨质疏松性不稳定转子间骨折临床效果观察。方法选取丽水市中心医院2014年2月～2016年7月收治的100例高龄骨质疏松性不稳定转子间骨折患者为研究对象,随机分为对照组和实验组,每组患者为50例。对照组进行常规治疗（鲑降钙素）,实验组患者进行唑来膦酸治疗,比较分析2组患者相关临床指标。结果经过对应的治疗后,实验组与对照组VAS评分分别为（0.36±0.42）与（0.34±0.40）,差异无统计学意义。对照组髋关节功能优良率为82.0%,实验组髋关节功能优良率为80.0%,差异无统计学意义。另外,2组患者骨折愈合时间与并发症发生情况差异均无统计学意义。术后1年,实验组患者髋部骨密度与腰椎骨密度分别为（0.78±0.05）g/cm^2与（0.85±0.06）g/cm^2显著高于对照组,差异具有统计学意义（P〈0.05）。结论唑来膦酸治疗高龄骨质疏松性不稳定转子间骨折临床效果较为显著,能够在很大程度上提高患者骨密度,对关节恢复并无影响。

Objective To study and analyze the clinical efficacy of zoledronic acid in the treatment of osteoporotic intertrochanteric fracture in elderly patients.Methods 100 elderly patients with osteoporotic unstable intertrochanteric fracture treated in our hospital from February 2014 to July 2016 were selected and randomly divided into the control group and the experimental group.There were 50 patients in each group.The control group received routine treatment（calcitonin）,and the experimental group was treated with zoledronic acid.The clinical indicators of the two groups were compared and analyzed.Results After the corresponding treatment,the VAS scores of the experimental group and the control group were（0.36±0.42） and（0.34±0.40）,and there was no statistical significance.The excellent rate of hip joint function was 82% in the control group,and the excellent and good rate of hip joint function in the experimental group was 80%,which was not statistically significant.In addition,there were no statistically significant differences in fracture healing time and complications between the two groups.After 1 years,the hip bone mineral density and the lumbar vertebral bone mineral density were（0.78±0.05） g/cm^2,and（0.85±0.06） g/cm^2 were significantly higher than those in the control group,with statistical significance（P〈0.05）.Conclusion Zoledronic acid in the treatment of senile osteoporotic unstable intertrochanteric fracture clinical effect is remarkable,can increase bone mineral density in a large extent,the joint recovery had no effect,has clinical significance.