养胃颗粒对Hp阳性慢性糜烂性胃炎患者血清炎症因子及Hp转阴率的影响

Study on the effect of Yangwei granules on Hp positive chronic erosive gastritis serum inflammatory factor and the negative rate of Hp

目的探讨养胃颗粒对Hp阳性慢性糜烂性胃炎患者血清炎症因子及Hp转阴率的影响。方法选取湖州市南浔区人民医院消化内科2015年2月～2016年6月收治的Hp阳性慢性糜烂性胃炎患者92例,按随机数字表法分为对照组和研究组,分别为46例。对照组予以根除Hp标准方案;研究组予以养胃颗粒治疗。比较2组治疗前后血清IL-2R、IL-6、TNF-α水平和Hp转阴率。结果与对照组比较,研究组治疗后血清IL-2R、IL-6、TNF-α较低;对照组Hp转阴率69.57%,研究组Hp转阴率89.13%,研究组高于对照组（P〈0.05）;对照组有效率73.91%,研究组有效率91.31%,研究组高于对照组（P〈0.05）。结论养胃颗粒有利于降低Hp阳性慢性糜烂性胃炎患者炎症反应,提高临床疗效和Hp根除率,安全性高。

Objective To investigate the Yangwei granules on Hp positive chronic erosive gastritis and inflammatory factors in the patients with HP negative rate effect.Methods 92 Hp positive patients with chronic erosive gastritis from February 2015 to June 2016 were randomly divided into control group and study group,46 cases respectively.The control group was given Hp eradication standard scheme;the study group to Yangwei granules treatment.The levels of serum IL-2 R,IL-6,TNF-α,and Hp were compared before and after treatment.Results Compared with the control group,serum IL-2 R,IL-6,TNF-α alpha of the study group after treatment is lower.The negative rate of Hp in the control group was 69.57%,and the negative rate of Hp in the study group was 89.13%,（P〈0.05）.The effective rate of the control group was 73.91%,and the effective rate of the study group was 91.31%（P〈0.05）.Conclusion Yangwei granule can reduce inflammation in patients with Hp positive chronic erosive gastritis the reaction,improve the clinical efficacy and eradication rate of Hp,high safety.