单唾液酸四己糖神经节苷脂钠联合依达拉奉对急性脑梗死患者血清Hcy和hs-CRP的影响

Effects of monosialonic acid tetrahexose ganglioside sodium and edaravone on serum Hcy and hs-CRP in patients with acute cerebral infarction

目的探讨单唾液酸四己糖神经节苷脂钠（GM-1）与依达拉奉联合治疗对急性脑梗死（ACI）患者血清同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）的影响。方法将ACI患者66例随机分为观察组与对照组,各33例,均予以神经内科常规治疗,对照组加用依达拉奉,观察组加用依达拉奉和GM-1。对比2组的疗效、神经功能缺损量表（NIHSS）评分、血清hs-CRP、Hcy水平。结果观察组治疗总有效率为90.91%,明显高于对照组的69.70%（P〈0.05）;治疗21 d后,观察组的NIHSS评分、血清Hcy、hs-CRP显著低于对照组（P〈0.05）。结论 GM-1联合依达拉奉治疗ACI疗效确切,能够促进神经功能及生活活动功能康复,其作用机制可能与其抗炎性反应、降低Hcy水平、保护脑细胞损伤有关。

Objective To investigate the effects of monosodium tetrahexose ganglioside sodium（GM-1） combined with edaravone in the treatment of acute cerebral infarction（ACI） in patients with serum homocysteine（Hcy）,high sensitivity C-reactive protein（Hs-CRP）.Methods 66 patients with ACI were randomly divided into observation group and control group,33 cases were treated with conventional neurology.The control group was treated with edaravone.The observation group was treated with edaravone and GM-1.（NIHSS） score,serum hs-CRP and Hcy levels were compared between the two groups.Results The total effective rate of the observation group was 90.91%,which was significantly higher than that of the control group（P〈0.05）.After 21 days of treatment,the NIHSS score,serum Hcy and hs-CRP in the observation group were significantly lower than those in the control group（P〈0.05）.Conclusion GM-1 combined with edaravone is effective in the treatment of ACI,which can promote the rehabilitation of neurological function and living activity.Its mechanism may be related to its anti-inflammatory response,reduced Hcy level and protection of brain cell injury.