盐酸非索非那定片联合卡介菌多糖核酸治疗慢性荨麻疹的疗效观察

Effects observation of Fexofenadine hydrochloride tablets combined with BCG polysaccharide nucleic acid in the treatment of chronic urticaria

目的分析盐酸非索非那定片联合卡介菌多糖核酸治疗慢性荨麻疹临床疗效。方法选取义乌市皮肤病医院2016年1月～2017年3月收治的122例慢性荨麻疹患者为研究对象,随机分为对照组和实验组,每组61例。对照组进行盐酸非索非那定片治疗,实验组在对照组基础上给予卡介菌多糖核酸治疗。实验组与对照组患者治疗时间均为3个月,比较2组患者治疗效果与不良反应发生情况。结果经过对应治疗后,实验组中,无效例数为10例。对照组中,21例无效。可得,实验组治疗有效率为63.93%显著高于对照组有效率32.79%,差异具有统计学意义（P〈0.05）。2组患者均未出现明显不良反应,不良反应发生率差异并无统计学意义。治疗后,实验组积分（3.20±0.42）显著低于对照组积分（3.98±0.37）,差异具有统计学意义（P〈0.05）。结论盐酸非索非那定片联合卡介菌多糖核酸治疗慢性荨麻疹临床疗效较为理想,能够显著改善患者临床症状,安全性较高。

Objective To study clinical effects of the fexofenadine hydrochloride Tablets and BCG-PSN in the treatment of chronic urticaria.Methods 122 patients with chronic urticaria treated in Yiwu skin disease hospital from January 2016 to March 2017 were selected and randomly divided into the control group and the experimental group,61 patients for each group.The control group was given Fexofenadine Hydrochloride Tablets treatment,the experimental group was given BCG-PSN on the basic treatment of the control group.The patients in the experimental group and the control group were treated for 3 months.The treatment effect and adverse reactions were compared between two groups.Results After the corresponding treatment,the number of invalid cases in the experimental group was 10.In the control group,21 cases were ineffective.The effective rate of the experimental group was 63.93%,which was significantly higher than 32.97% of the control group with statistical significance（P〈0.05）.There were no obvious adverse reactions in the two groups,and there was no significant difference in the incidence of adverse reactions.After treatment,the integral score of the experimental group was（3.20±0.42）,significantly lower than that of the control group（3.98±0.37）,with statistical significance（P〈0.05）.Conclusion fexofenadine hydrochloride Tablets combined with BCG-PSN for the treatment of chronic urticaria could significantly improve clinical symptoms of patients with good efficacy,high safety and clinical application significance.