丁丙诺芬透皮贴剂联合帕瑞昔布纳针在人工膝关节置换术的长效镇痛效果

Buprenorphine fentanyl transdermal system combined gone.love Buna needle in artificial knee joint replacement long-acting analgesic effect

目的分析丁丙诺芬透皮贴剂联合帕瑞昔布纳针在人工膝关节置换术后长效镇痛效果。方法选取舟山广安医院2015年2月～2016年8月收治的60例进行人工膝关节置换术患者为研究对象,随机分为对照组和实验组,每组患者各为30例。术后对照组给予帕瑞昔布纳针,实验组在此基础上给予丁丙诺芬透皮贴剂。若2组患者疼痛视觉模拟评分大于5时,给予盐酸曲马多缓释片。比较分析实验组与对照组患者镇痛效果。结果治疗第7天,实验组静息疼痛评分为（1.11±0.43）,显著低于对照组评分（2.50±0.68）,差异具有统计学意义（P〈0.05）。治疗后第7天,实验组曲马多单日用量为（210.09±20.90）mg,显著少于对照组用量（1123.90±60.90）mg,差异具有统计学意义（P〈0.05）。2组患者均未出现明显不良反应,差异无统计学意义。结论丁丙诺芬透皮贴剂联合帕瑞昔布纳针在人工膝关节置换术后的应用,镇痛作用较为显著,能够在一定程度上减少止痛药用量,可能的不良反应仍需观察。

Objective To study the transdermal buprenorphine Finland combined needle in patients in Buner after total knee arthroplasty long-acting analgesic effect.Methods 60 cases of total knee arthroplasty in Zhoushan Guang＇an Hospital from February 2015 to August 2016 were selected as the study subjects,and were randomly divided into the control group and the experimental group,each group had 30 cases.The postoperative patients in control group were given Bouna needle,given buprenorphine finland transdermal patch on the basis of the experimental group.If the visual analogue scale of the two patients was greater than 5,tramadol hydrochloride sustained release tablets was given.The analgesic effects of the experimental group and the control group were compared and analyzed.Results After seventh days of treatment,the resting pain score of the experimental group was（1.11±0.43）,significantly lower than that of the control group（2.50±0.68）,with statistical significance（P〈0.05）.Seventh days after treatment,the daily dose of tramadol in the experimental group was（210.09±20.90） mg,significantly less than that of the control group（1 123.90±60.90） mg,with statistical significance（P〈0.05）.There were no obvious adverse reactions in the two groups,and there was no significant difference.Conclusion The application of buprenorphine transdermal patches combined with finland gone.love Buna needle in artificial knee joint replacement surgery,the analgesic effect is obvious,can to some extent reduce the dosage of analgesic,side effects may still need to observe.