替勃龙联合阿仑膦酸钠对围绝经期及绝经后妇女骨质疏松症的疗效观察

Tibolone combined with alendronate on curative effect of osteoporosis of women in perimenopausal and postmenopausal women

目的研究分析替勃龙联合阿仑膦酸钠对围绝经期及绝经后妇女骨质疏松症的疗效观察。方法选取苍南县第二人民医院2015年4月～2016年10月收治的126例围绝经期及绝经后妇女骨质疏松症患者为研究对象,随机分为对照组和实验组,每组患者各为63例。对照组患者给予口服阿仑磷酸钠、碳酸钙D3片治疗及锻炼康复指导,实验组患者在对照组基础上联合替勃龙治疗。实验组与对照组患者治疗时间均为48周。比较分析实验组与对照组患者的治疗效果。结果治疗后,实验组63例患者中,16例患者无效,47例患者治疗有效。对照组63例患者中,58例患者有效,5例患者治疗无效。可得,实验组患者的治疗有效率（92.1%）显著高于对照组（74.6%）,差异具有统计学意义（P〈0.05）。结论替勃龙联合阿仑膦酸钠治疗围绝经期及绝经后妇女骨质疏松症临床效果较好,治疗有效率较高,安全性较高,具有临床推广的意义。

Objective To study the analysis of tibolone combined with alendronate on curative effect of osteoporosis of women in perimenopausal and postmenopausal women.Methods 126 cases of perimenopausal and postmenopausal women with osteoporosis were selected from April 2015 to October 2016 in our hospital.The subjects were randomly divided into the control group and the experimental group,with 63 patients in each group.The control group were treated with oral compound amino acid chelated calcium treatment,the patients in the experimental group of tibolone combined with alendronate sodium.The treatment time of the experimental group and the control group was in December.The therapeutic effects of the experimental group and the control group were compared and analyzed.Results After the corresponding treatment,63 patients in the experimental group,16 patients were invalid,and 47 patients were effective.Of the 63 patients in the control group,58 patients were ineffective,and 5 patients were treated effectively.The effective rate of treatment in the experimental group（92.1%） was significantly higher than that in the control group（74.6%）,with statistical difference（P〈0.05）.In the experimental group,4 patients had side effects,and 3 cases in the control group had side effects.There was no significant difference in the incidence of adverse reactions between the two groups,and there was no statistical difference.Conclusion Tibolone combined with alendronate sodium in the treatment of the clinical effect of women with osteoporosis in perimenopausal and postmenopausal women,high treatment efficiency,high safety,has clinical significance.