骨肽注射液对骨关节骨性关节炎患者碱性磷酸酶活性的影响

Effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase

目的分析骨肽注射液对骨关节骨性关节炎患者碱性磷酸酶活性的影响。方法选取山西省中医院2015年3月～2017年5月收治的74例骨关节骨性关节炎患者,随机分为2组各37例,对照组以硫酸氨基葡萄糖治疗,观察组以骨肽注射液治疗,比较2组治疗效果及碱性磷酸酶活性。结果观察组治疗总有效率为97.30%,明显高于对照组的70.27%（P〈0.05）。治疗后观察组膝关节功能评分（79.62±5.80）分,明显高于对照组的（71.06±5.41）分（P〈0.05）。治疗30 d、45 d后碱性磷酸酶活性（0.97±0.12）nkat/L、（1.39±0.12）nkat/L明显高于对照组的（0.71±0.10）nkat/L、（0.88±0.10）nkat/L,不良反应发生率5.41%明显低于对照组的24.32%（P〈0.05）。结论骨肽注射液对骨关节骨性关节炎患者有显著治疗效果,可有效改善患者膝关节功能,提高患者碱性磷酸酶活性,且用药安全性高。

Objective To analyze the effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase.Methods A total of 74 patients with osteoarthritis of the bone were selected from March 2015 to May 2017 in our hospital and were randomly divided into two groups,with 37 cases in each group.The control group was treated with glucosamine sulfate,the observation group was treated with ossotide injection.The therapeutic effect and alkaline phosphatase activity were compared between two groups.Results The total effective rate was 97.30% in the observation group,which was significantly higher than that in the control group（70.27%）（P〈0.05）.The score of knee function was（79.62±5.80） in the observation group.which was significantly higher than that in the control group（71.06±5.41）（P〈0.05）.The alkaline phosphatase activity after the treatment of 30 d and 45 d（0.97±0.12）,nkat/L（1.39±0.12） nkat/L was significantly higher than the control group（0.71±0.10）,nkat/L,（0.88±0.10） nkat/L,the incidence rate of adverse reaction（5.41 %） was significantly lower than the control group（24.32 %）（P〈0.05）.Conclusion Bone peptide injection has significant therapeutic effect on bone and joint osteoarthritis,can effectively improve the knee joint function of the patients,improve the patients with alkaline phosphatase activity,and high safety,is worthy of promotion.