尿激酶联合心理干预治疗IgA肾病的临床疗效分析

Analysis on the effect of urokinase and methylprednisolone combined with psychological intervention on the treatment of the patients with IgA nephropathy

目的分析尿激酶联合甲泼尼龙治疗IgA肾病患者的临床疗效分析及心理干预。方法选取2015年2月～2016年9月收治的100例IgA肾病患者为研究对象,随机分为对照组和试验组,每组50例。对照组给予甲泼尼龙治疗,试验组在激素治疗基础上给予尿激酶治疗,并进行心理干预,关注患者的心理状态,加强与患者的沟通和交流,增加患者的治疗信心和治疗依从性。比较分析试验组与对照组患者的治疗效果。结果试验组患者中,3例无效,27例有效。对照组患者中,18例患者无效,24例患者有效。试验组患者的治疗有效率94.0%显著高于对照组的64.0%,差异具有统计学意义（P〈0.05）。治疗后,试验组患者的24 h蛋白尿水平为（0.541±0.322）g/L显著低于对照组,差异具有统计学意义（P〈0.05）。结论尿激酶联合心理干预治疗IgA肾病患者的临床疗效较为理想,能够显著提高治疗有效率。

Objective To study the effect of urokinase and methylprednisolone combined with psychological intervention on the treatment of the patients with IgA nephropathy.Methods 100 patients with IgA nephropathy treated in our hospital from February 2015 to September 2016 were randomly divided into the control group and the experimental group,with 50 patients in each group.The control group were treated with methylprednisolone,the experimental group were treated with urokinase combined with methylprednisolone and psychological intervention.Pay attention to the psychological state of the,strengthen communication and exchanges,increase confidence and compliance of the patients in the treatment.The therapeutic effects of the experimental group and the control group were compared and analyzed.Results 3 patients in the experimental group were ineffective,and 27 patients were effective.In the control group,18 patients were ineffective and 24 patients were effective.The effective rate in the experimental group was 94%,which was significantly higher than that in the control group（64%）,with statistical difference（P〈0.05）.After treatment,the level of 24 h proteinuria in the experimental group was（0.541±0.322） g/L,significantly lower than that in the control group,with statistical difference（P〈0.05）.Conclusion The clinical curative effect of urokinase combined with methylprednisolone in the treatment of patients with IgA nephropathy is ideal,which can significantly improve the treatment efficiency,has clinical significance.