心理干预在齐拉西酮治疗精神分裂症所致不良反应中的应用效果

Effect of psychological intervention on the side effects of ziprasidone in the treatment of schizophrenia

目的探讨齐拉西酮、心理干预联合应用于精神分裂症治疗过程中对其药物相关不良反应的影响效果。方法选取绍兴市第七人民医院于2016年1月～2017年1月期间收治的62例精神分裂症患者,经单双数字法均分为研究组（n=31）、对照组（n=31）。对照组接受齐拉西酮治疗,研究组在齐拉西酮药物治疗基础上加用相应心理干预,记录2组治疗前后PANSS量表评分变化情况、药物相关不良反应发生情况。结果治疗前2组PANSS量表评分对比差异无统计学意义,治疗后研究组PANSS量表评分显著优于对照组（P〈0.05）;治疗期间研究组失眠（或嗜睡）、胃肠道反应、头痛、头晕等药物相关不良反应发生情况显著低于对照组（P〈0.05）。结论在采用齐拉西酮治疗精神分裂症基础上加用心理干预可降低药物相关不良反应,有效提高治疗效果。

Objective To explore the effects of ziprasidone combined with psychological intervention on drug related adverse reactions in the treatment of schizophrenia.Methods 62 patients with schizophrenia collected in Shaoxing seventh people＇s hospital from January 2016 to January 2017 were divided into study group（n=31） and control group（n=31） by single and double digital methods.The control group were received ziprasidone,the study group were received ziprasidone combined with psychological intervention.PANSS score and drug related adverse reactions in the two groups were recorded.Results Before treatment,PANSS score in the two groups has no statistical difference.PANSS score in the study group were decreased significantly than that in the control group（P〈0.05）.Insomnia or sleepiness,gastrointestinal reactions,headache,dizziness and other drug related adverse reactions in the study goup were significantly lower than those in the control group（P〈0.05）.Conclusion In schizophrenia treatment,ziprasidone combined with psychological intervention can effectively improve the therapeutic effect on the basis of reducing drug-related adverse reactions.