乳腺癌根治术患者应用多西紫杉醇联合卡培他滨化疗及心理干预的疗效分析

Application of docetaxel combined capecitabine chemotherapy and psychological intervention after radical mastectomy for breast cancer

目的探讨乳腺癌根治术后应用多西紫杉醇、卡培他滨化疗联合心理干预临床效果。方法选取浙江绍兴第二医院2011年2月～2012年8月收治的94例乳腺癌根治术后化疗患者作为本次研究对象,经单双数字法（入院就诊顺序）随机均分为研究组和对照组,每组47例。2组乳腺癌患者均接受乳腺癌根治性手术,术后提供多西紫杉醇、卡培他滨化疗。对照组术后化疗期间仅提供常规护理措施,研究组在对照组基础上加用心理干预。结果研究组总生存率、无进展生存期终点事件几率、无瘤生存率显著高于对照组（P〈0.05）;化疗期间研究组不良反应发生情况显著少于对照组（P〈0.05）。结论乳腺癌根治术后应用多西紫杉醇、卡培他滨联合化疗基础上给予常规护理加用心理干预可显著提高患者中期疗效并降低化疗相关不良反应。

Objective To investigate the clinical effect of docetaxel and capecitabine combined with psychological intervention after radical mastectomy for breast cancer.Methods A total of 94 patients with chemotherapy for radical mastectomy from February 2011 to August 2012 were selected as the subjects of this study.They were randomly divided into study group and control group by single and double numbers（admission order） Group,47 patients in each group.Two groups of patients with breast cancer underwent radical mastectomy,and postoperative docetaxel and capecitabine chemotherapy were performed.The control group received only routine nursing measures after the chemotherapy,and the study group was given psychological intervention on the basis of the control group.Results The overall survival,progression free survival end point event survival rate in the study group was significantly higher than the control group（P〈0.05）.During chemotherapy,the incidence of adverse reactions in the study group was significantly less than the control group（P〈0.05）.Conclusion After the radical mastectomy,the combination of docetaxel and capecitabine combined with chemotherapy,routine care and psychological intervention can significantly improve the medium-term efficacy and reduce the adverse reactions associated with chemotherapy.