吴茱萸抗大鼠应激性胃溃疡研究

Evodia rutaecarpa protects against the irritability gastric ulcer in rats

[目的]研究吴茱萸对大鼠应激性胃溃疡的作用及其可能的机制。[方法]实验分为空白对照组、水浸-束缚应激性(WRS)胃溃疡模型组及模型加吴茱萸生药0.45 g/kg体质量组、0.9 g/kg体质量组和1.8 g/kg体质量组,计算各组大鼠胃溃疡指数;采用高效液相色谱-电化学法(HPLC-ECD)检测大鼠血清肾上腺素(E)水平。[结果]吴茱萸0.45 g/kg组能显著降低溃疡指数(P<0.05)抑制溃疡形成。与模型组相比吴茱萸给药组均能显著抑制血清中E含量(P<0.05)。[结论]吴茱萸具有抗大鼠应激性胃溃疡的作用,其作用机制可能与调节血清中E含量有关。

[Objective] To investigate the effect of Evodia rutaecarpa in irritability gastric ulcer of rats and its possible mechanism. [Methods] Wistar rats were randomly divided into normal control group, water-immersion restraint stress induced gastric ulcer model group, model and Evodia rutaecarpa 0.45 g/kg group, Evodia rutaecarpa 0.9 g/kg group, and Evodia rutaecarpa 1.8 g/kg group, calculate the gastric ulcer index of rats in each group. The level of serum epinephrine in rats was detected by high performance liquid chromatography with electrochemical method. [Results] Evodia rutaecarpa 0.45 g/kg group could significant reduce ulcer index （ P〈0.05） and inhibit ulcer formation. Compared with model group, every Evodia rutaecarpa group could definitely inhibit E content in serum. [Conclusion] Evodia rutaecarpa had the effect on inhibition of the irritability gastric ulcer, and its mechanism can be related to regulate content in serum.