超临界流体快速膨胀过程制备药物微粒的研究进展

Research progress on preparation of drug microparticles by rapid expansion of supercritical solution

介绍了RESS过程的原理及其在制备药物微粒方面的应用,重点综述了操作过程中的温度、压力、喷嘴结构、喷射距离、助溶剂及产品收集环境等参数对制得粒子形貌的影响,讨论了近年来RESS过程制备药物微粒的新进展。此外,还分析了RESS过程在实用中仍存在的一些问题,并展望了今后的研究方向。

This paper introduces the principle of rapid expansion of supercritical solution（RESS） and its application in the preparation of drug microparticles. The influences of temperature,pressure,structure of the nozzle,spraying distance,co-solvent and product collection environment on particle ＇s morphology prepared are summarized emphatically.The development and new progress on the preparation of drug microparticles using RESS in recent years are discussed.In addition,the problems existed in the practical use of RESS are analyzed and the future research direction is expected.