口腔癌术后患者甲状腺功能低下的高危因素分析

Risk factors of thyroid dysfunction in postoperative patients with oral cancer

目的:探讨口腔癌术后患者甲状腺功能低下的高危因素。方法:回顾性分析我院从2012年7月~2017年5月收治的156例口腔癌患者的临床特征与术后甲状腺功能低下的相关性。结果:156例患者手术前均无甲状腺功能降低,术后有35例患者有甲状腺低下,比例为22.44%。在102例接受放疗的患者中,甲低患者的比例为28.43%,而未接受放疗的54例患者发生甲状腺低下的比例为11.11%,其差异具有统计学意义(P=0.014)。结论:口腔癌术后放疗是导致甲状腺功能低下的高危因素。

Objective： To investigate the risk factors of hypothyroidism in patients with oral cancer after operation.Methods： Retrospective analysis of the correlation between the clinical characteristics of 156 oral cancer patients treated in our hospital from Jul 2012 to May 2017 and the incidence of postoperative hypothyroidism. Results： None of patients had hypothyroidism before surgery. Thirty-five patients had hypothyroidism at 22. 44%. Of the 102 patients receiving radiotherapy,the proportion of patients with hypothyroidism was 28. 43%,compared with 11. 11% in 54 patients who did not receive radiotherapy,the difference was statistically significant（ P = 0. 014）. Conclusion： Postoperative radiotherapy of oral cancer is a high risk factor leading to hypothyroidism.