二氯甲烷职业接触内外暴露水平的关系研究

Study on the relationship between internal and external levels after occupational exposure to dichloromethane

目的探讨职业接触二氯甲烷的生物接触限值。方法以50名职业接触二氯甲烷工人为接触组,另选择同一企业43名行政人员为对照组,检测工作场所空气中二氯甲烷水平,以及作业工人班末尿中的二氯甲烷水平,并进行两者间的相关分析,制订二氯甲烷的生物接触限值。结果班末尿中二氯甲烷水平与工作场所空气中二氯甲烷时间加权平均浓度具有相关性(决定系数为0.962,P<0.05),回归方程为y=0.001 1x+0.038 8(P<0.001)。结论劳动者职业接触二氯甲烷后尿中内暴露与外暴露之间存在剂量-效应关系,为制定我国职业接触二氯甲烷的生物限值提供了科学依据。

Objective To explore the biological exposure limit of occupational exposure to dichloromethane in the workplace. Methods Fifty workers exposed to dichloromethane were selected as the exposed group and 43 administrative staff as the control group. The concentrations of dichloromethane in the air of workplace and urinary dichloromethane for all subjects were determined. The correlation factors between both groups were calculated. Urinary exposure limit of dichloromethane was developed according to exposure limit of dichloromethane in the air of workplace. Results The dichloromethane level in the urine at the end of the working hours was correlated with the time-weighted average concentration of dichloromethane in the workplace air （ coefficient of determination was0. 916,P 〈0. 05） . The regression equation was y = 0.001 1 x ＋ 0.038 8 （P 〈0.001）. Conclusions It was suggested that the limit of urinary methylene chloride was 0. 300 0 mg/L for those exposed to dichloromethane.