酪酸梭菌对慢性胃炎及消化道溃疡伴幽门螺杆菌感染治疗效果的Meta分析

Meta-analysis on the efficacy of clostridium butyricum onchronic gastritis and peptic ulcer with Helicobacter pylori infection

目的采用Meta分析方法,评价酪酸梭菌在治疗慢性胃炎及消化道溃疡伴幽门螺杆菌感染的临床效果及降低胃肠道反应的疗效。方法计算机检索Pubmed、中国知网、万方、维普等常用数据库中酪酸梭菌联合传统疗法(三联、四联疗法)与单独传统疗法治疗幽门螺杆菌感染的RCT研究,对符合纳入标准的RCT,由两位评价员按Cochrane系统评价的方法,独立进行资料提取、质量评价并交叉核对后,采用Rev Man 5.35软件进行Meta分析。分析幽门螺杆菌治疗有效率、根治率及不良反应发生率的合并RR值及发表偏倚。结果共9项RCT研究符合纳入标准,酪酸梭菌联合传统疗法与单独传统疗法相比,治疗有效率、根治率及不良反应发生率的合并RR值及95%CI分别为2.91(1.81~4.68)、3.52(2.49~4.97)和0.27(0.17~0.45)。结论酪酸梭菌联合传统疗法治疗慢性胃炎及消化道溃疡合并幽门螺杆菌的有效率、根治率及降低胃肠道不良反应的效果均优于单一传统疗法。

Objective To evaluate the clinical effect of Clostridium butyricum in the treatment of chronic gastritis and peptic ulcer with Helicobacter pylori infection through Meta-analysis. Methods Data of RCT studies on Clostridium butyricum combined traditional therapy （triple therapy and quadruple therapy） and traditional therapy alone for Helicobacter pylori infection were obtained from commonly used databases （ e. g. Pubmed、 CNKI,Wangfang Data, Weipu Database, Wanfang Database ） . RCTs that met the inclusion criteria were performed by two evaluators according to the Cochrane system evaluation method, information was independently collected, quality evaluation was performed and cross-checked. Finally Meta-analyzed with the software Rev Man 5. 35, to assess the effective rates,as well as the combined RR values of adverse reaction rates and radical rates reported in the selected literature. The publication bias of the literature was also assessed. Results Nine of the RCT studies met the inclusion criteria in total. Compared with the traditional therapy, the effective rate, combined RR value of adverse reaction rates and radical rate, and 95% CI of the clostridium butyricum combined traditional therapy were 2. 91 （ 1. 81 - 4. 68 ）, 3. 52 （ 2. 49 - 4. 97 ） and 0. 27 （ 0. 17 - 0. 45 ）, respectively. Conclusion The clostridium butyricum combined with traditional therapy had a better effectiveness in the treatment of gastric, duodenal and peptic ulcer with Helicobacter pylori infection, as compared with the traditional therapy alone.