康柏西普联合激光光凝治疗糖尿病性黄斑水肿疗效观察

Efficacy of conbercept combined with laser photocoagulation in the treatment for diabetic macular edema

目的探讨康柏西普联合激光光凝法治疗糖尿病性黄斑水肿的临床疗效,为糖尿病黄斑水肿的临床治疗提供参考。方法选取2015年10月至2016年10月收治住院治疗的糖尿病性黄斑水肿患者36例36眼为观察组,另选取2014年10月至2015年10月收治住院治疗的同类疾病患者36例36眼作为对照组。观察组采用玻璃体内注射康柏西普联合激光光凝治疗,对照组患者仅接受激光光凝治疗。比较两组患者治疗前、治疗后1个月、治疗后2个月的最佳矫正视力(BCVA)及中心视网膜厚度(CMT),并分析治疗中并发症的发生情况。结果两组治疗后BCVA及CMT均上升且均优于治疗前(P<0.05),观察组治疗后第1个月和第2个月的BCVA及CMT均高于对照组,差异有统计学意义(P<0.05)。两组治疗过程中主要并发症比较差异无统计学意义(P>0.05)。结论康柏西普联合激光光凝法治疗糖尿病性黄斑水肿,可较好地改善患者的最佳矫正视力和黄斑中心厚度,且术后并发症少,值得临床推广应用。

Objective To explore the clinical efficacy of conbercept combined with laser photocoagulation in the treatment of diabetic macular edema,and to provide reference for the clinical treatment of diabetic macular edema.Methods A total of 36 cases(36 eyes)of patients with diabetic macular edema from October 2015 to October 2016 were selected as the observation group.Another 36 cases(36 eyes)of similar diseases from October 2014 to October 2015 were chosen as the control group.The observation group were treated with intravitreal injection of conbercept combined with laser photocoagulation,and the control group received only laser photocoagulation.The best corrected visual acuity(BCVA)and central retinal thickness(CMT)were compared between the two groups before treatment,1 month after treatment and 2 months after treatment,and the incidence of complications in the treatment was analyzed.Results BCVA and CMT in the two groups after treatment were higher than those before treatment(P<0.05).BCVA and CMT of the observation group in the first and second months after treatment were higher than those in the control group and there were all difference between them(P<0.05).There was no significant difference in the main complications between the two groups(P>0.05).ConclusionConbercep combined with laser photocoagulation for the treatment of diabetic macular edema,can better improve the best corrected visual acuity and macular thickness,and less the postoperative complications,which is worthy of clinical application.