柑橘皮中辛弗林对营养型肥胖大鼠的减肥效果研究

Effects of Synephrine from Citrus Peel on Weight Losing of Nutritional Pinelosis Rats

研究柑橘皮中生物碱辛弗林对营养型肥胖大鼠的减肥功效。提取、分离柑橘皮中辛弗林,纯化。制备营养型肥胖大鼠模型,模型动物给药4周,观察大鼠体质量、体脂、血脂的变化。研究结果表明:与高脂组相比,辛弗林高、中剂量组能明显降低肥胖大鼠的体质量、Lee's指数、肾脏及睾丸周围脂肪重量(P<0.05),辛弗林高、中、低剂量组均能明显降低肥胖大鼠的肝脏、肾脏系数(P<0.05);辛弗林高剂量组肥胖大鼠的血清低密度脂蛋白胆固醇(LDL-C)、血清总胆固醇(TC)、血清甘油三酯(TG)含量均比高脂组显著降低(P<0.05);与高脂组比较,辛弗林高剂量组肥胖大鼠血清高密度脂蛋白胆固醇(HDL-C)含量明显上升(P<0.01)。表明柑橘皮中生物碱辛弗林对营养型肥胖大鼠有显著的减肥功效。

To study the effects of Synephrine from citrus peel on weight losing of nutritional pinelosis rats. Synephrine was extracted from Citrus peel and then purified and the model of diet-induced obese rats were prepared. Drugs were administered intragastrically to obese rats for 4 weeks. Then the changes in body weight,body fat,blood lipids should be observed. The high and the medium dose group of Synephrine can significantly reduce the weight of obese rats,the Lee＇s index and the weight of fat that around the kidney and testis （9〈0.05） ; The Liver and kidney coefficients of obese rats in high,medium and low dose group of Synephrine all significantly become lower（9〈0.05）; The content of the low density lipoprotein cholesterol （LDL-C ） ,total cholesterol （TC） and serum triglyceride （TG） of obese rats in high dose group of Synephrine is lower than the content that in the high lipid group（9〈0.05） ;While compared with the high lipid group, the content of the high density lipoprotein cholesterol （HDL- C ） of obese rats in high dose group of Synephrine is higher（9〈0.01）.Synephrine from citrus peel has significant effect on weight losing of nutritional pinelosis rats.