老年AIS患者的血清A-FABP和趋化因子CXCL12与AIS的发生及程度的关系

Relationship among serum A-FABP,chemokine CXCL12 and onset,severity of AIS in aged AIS patients

目的:探讨血清脂肪细胞型脂肪酸结合蛋白(A-FABP)和趋化因子CXCL12水平与老年急性缺血性脑卒中(AIS)的关系。方法:选择我院收治的老年AIS患者92例作为AIS组,同期在我院进行体检的83名健康者作为健康对照组。测定比较两组血清A-FABP和趋化因子CXCL12水平;采用美国国立卫生院神经功能缺损量表(NIHSS)评估患者神经功能缺损程度;采用格拉斯哥昏迷评分量表(GCS)判断其意识情况。随访3个月,采用改良Rankin量表(mRS)评价预后情况。结果:与健康对照组比较,AIS组血清A-FABP[(20.92±2.63)μg/L比(35.63±5.72)μg/L]和趋化因子CXCL12[(4.25±0.61)ng/ml比(24.31±3.46)ng/ml]水平均显著升高(P均=0.001)。与中小面积梗死组、NIHSS评分≤15分组、GCS评分≤8分组、预后良好组比较,大面积梗死组、NIHSS评分>15分组、GCS评分>8分组和预后不良组的血清A-FABP[(32.89±5.34)μg/L,(31.72±4.15)μg/L,(30.68±4.21)μg/L,(32.17±3.72)μg/L比(38.24±5.86)μg/L,(39.58±4.28)μg/L,(40.97±4.24)μg/L,(38.92±4.35)μg/L;趋化因子CXCL12[(21.38±3.18)ng/ml,(21.03±2.45)ng/ml,(20.78±2.42)ng/ml,(21.54±2.67)ng/ml比(28.26±3.37)ng/ml,(27.18±2.94)ng/ml,(27.51±2.89)ng/ml,(27.23±3.15)ng/ml]水平均显著升高(P均<0.01)。结论:老年AIS患者的血清A-FABP和趋化因子CXCL12水平与AIS的发生及严重程度关系密切,可以作为其早期诊断、病情监控及预后评估的重要临床指标。

Objective：To explore relationship among serum levels of adipocyte fatty acid binding protein （A-FABP）, chemokine CXCL12 and acute ischemic stroke （AIS）.Methods：A total of 92 aged AIS patients treated in our hospi-tal were selected as AIS group,another 83 healthy subjects undergoing physical examination in our hospital were en-rolled as healthy control group.Serum levels of A-FABP and chemokine CXCL12 were measured and compared be-tween two groups;United states national institutes of health stroke score （NIHSS）was used to assess neurological function deficit degree;Glasgow coma scale （GCS）was used to judge their consciousness.AIS patients were fol-lowed up for three months,then modified Rankin rating score （mRS）was used to assess their prognosis.Results：Compared with healthy control group,there were significant rise in serum levels of A-FABP [（20.92±2.63）μg/L vs.（35.63±5.72）μg/L]and chemokine CXCL12 [（4.25 ±0.61 ）ng/ml vs.（24.31 ±3.46）ng/ml]in AIS group,P =0.001 both.Compared with small-medium size infraction group,NIHSS score≤15 scores group,GCS score≤8 scores group and good prognosis group,the levels of FABP [（32.89±5.34）μg/L,（31.72±4.15）μg/L, （30.68±4.21）μg/L,（32.17±3.72）μg/L vs.（38.24±5.86 ）μg/L,（39.58±4.28）μg/L,（40.97±4.24）μg/L,（38.92±4.35）μg/L;chemokine CXCL12 [（21.38±3.18）ng /ml, （21.03 ±2.45）ng/ml,（20.78±2.42） ng/ml,（21.54±2.67）ng/ml vs.（28.26±3.37）ng/ml,（27.18±2.94）ng/ml,（27.51±2.89）ng/ml,（27.23±3.15）ng/ml]significantly rose （P 〈0.01 all）in large size infarction group,NIHSS score 〉 15 scores group,GCS score〉8 scores group and poor prognosis group.Conclusion：Serum levels of A-FABP and chemokine CXCL12 are closely related to occurrence and severity of AIS,which can be used as important indexes for early diagnosis,disease monitor and prognosis assessment in AIS patients.