摘要
目的:探讨血清脂肪细胞型脂肪酸结合蛋白(A-FABP)和趋化因子CXCL12水平与老年急性缺血性脑卒中(AIS)的关系。方法:选择我院收治的老年AIS患者92例作为AIS组,同期在我院进行体检的83名健康者作为健康对照组。测定比较两组血清A-FABP和趋化因子CXCL12水平;采用美国国立卫生院神经功能缺损量表(NIHSS)评估患者神经功能缺损程度;采用格拉斯哥昏迷评分量表(GCS)判断其意识情况。随访3个月,采用改良Rankin量表(mRS)评价预后情况。结果:与健康对照组比较,AIS组血清A-FABP[(20.92±2.63)μg/L比(35.63±5.72)μg/L]和趋化因子CXCL12[(4.25±0.61)ng/ml比(24.31±3.46)ng/ml]水平均显著升高(P均=0.001)。与中小面积梗死组、NIHSS评分≤15分组、GCS评分≤8分组、预后良好组比较,大面积梗死组、NIHSS评分>15分组、GCS评分>8分组和预后不良组的血清A-FABP[(32.89±5.34)μg/L,(31.72±4.15)μg/L,(30.68±4.21)μg/L,(32.17±3.72)μg/L比(38.24±5.86)μg/L,(39.58±4.28)μg/L,(40.97±4.24)μg/L,(38.92±4.35)μg/L;趋化因子CXCL12[(21.38±3.18)ng/ml,(21.03±2.45)ng/ml,(20.78±2.42)ng/ml,(21.54±2.67)ng/ml比(28.26±3.37)ng/ml,(27.18±2.94)ng/ml,(27.51±2.89)ng/ml,(27.23±3.15)ng/ml]水平均显著升高(P均<0.01)。结论:老年AIS患者的血清A-FABP和趋化因子CXCL12水平与AIS的发生及严重程度关系密切,可以作为其早期诊断、病情监控及预后评估的重要临床指标。
Objective:To explore relationship among serum levels of adipocyte fatty acid binding protein (A-FABP), chemokine CXCL12 and acute ischemic stroke (AIS).Methods:A total of 92 aged AIS patients treated in our hospi-tal were selected as AIS group,another 83 healthy subjects undergoing physical examination in our hospital were en-rolled as healthy control group.Serum levels of A-FABP and chemokine CXCL12 were measured and compared be-tween two groups;United states national institutes of health stroke score (NIHSS)was used to assess neurological function deficit degree;Glasgow coma scale (GCS)was used to judge their consciousness.AIS patients were fol-lowed up for three months,then modified Rankin rating score (mRS)was used to assess their prognosis.Results:Compared with healthy control group,there were significant rise in serum levels of A-FABP [(20.92±2.63)μg/L vs.(35.63±5.72)μg/L]and chemokine CXCL12 [(4.25 ±0.61 )ng/ml vs.(24.31 ±3.46)ng/ml]in AIS group,P =0.001 both.Compared with small-medium size infraction group,NIHSS score≤15 scores group,GCS score≤8 scores group and good prognosis group,the levels of FABP [(32.89±5.34)μg/L,(31.72±4.15)μg/L, (30.68±4.21)μg/L,(32.17±3.72)μg/L vs.(38.24±5.86 )μg/L,(39.58±4.28)μg/L,(40.97±4.24)μg/L,(38.92±4.35)μg/L;chemokine CXCL12 [(21.38±3.18)ng /ml, (21.03 ±2.45)ng/ml,(20.78±2.42) ng/ml,(21.54±2.67)ng/ml vs.(28.26±3.37)ng/ml,(27.18±2.94)ng/ml,(27.51±2.89)ng/ml,(27.23±3.15)ng/ml]significantly rose (P 〈0.01 all)in large size infarction group,NIHSS score 〉 15 scores group,GCS score〉8 scores group and poor prognosis group.Conclusion:Serum levels of A-FABP and chemokine CXCL12 are closely related to occurrence and severity of AIS,which can be used as important indexes for early diagnosis,disease monitor and prognosis assessment in AIS patients.
出处
《心血管康复医学杂志》
CAS
2017年第5期463-466,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine