丹参酮注射液并地尔硫卓对高血压患者血管内皮功能的影响

Influence of tanshinone injection combined diltiazem on vascular endothelial function in patients with hypertension

目的:探讨丹参酮注射液联合地尔硫卓治疗对高血压患者血管内皮功能的影响。方法:选择我院住院治疗的原发性高血压患者136例,通过随机数字表法分为联合治疗组(应用丹参酮注射液联合地尔硫卓治疗)和地尔硫卓组,各68例,比较治疗前,治疗后2周、1个月两组患者的血压、内皮依赖的舒张功能(EDD)的变化。结果:与治疗前比较,治疗2周及治疗1个月后,两组血压明显下降[治疗前:联合治疗组(168.25±12.54)/(112.47±6.28)mm Hg,地尔硫卓组(168.37±11.74)/(112.49±7.13)mm Hg,治疗2周:(142.37±2.43)/(100.43±5.19)mm Hg比(151.36±6.16)/(109.17±4.76)mm Hg,治疗1个月:(126.71±8.17)/(87.49±5.37)mm Hg比(142.34±6.28)/(94.16±6.28)mm Hg],且联合治疗组血压较地尔硫卓组降低更显著,P均<0.01;与治疗前比较,治疗2周及治疗1月后,两组EDD均较治疗前明显提高[治疗前与治疗1个月后比较(4.78±2.30)%比(8.43±4.73)%比(4.74±2.26)%比(6.69±4.60)%],且联合治疗组治疗1个月后EDD值较地尔硫卓组提高更显著(P<0.05或<0.01)。结论:高血压患者在应用地尔硫卓的同时配合应用丹参酮注射液有助于改善血管内皮功能。

Objective：To explore influence of tanshinone injection combined diltiazem on vascular endothelial function in patients with hypertension.Methods：A total of 136 inpatients with essential hypertension were selected from our hospital. According to random number table,they were randomly and equally divided into diltiazem group and combined treatment group （received tanshinone injection combined diltiazem）.Blood pressure,endothelium dependent dilation （EDD）were compared between two groups before,two weeks and one month after treatment.Results：Compared with before treatment [combined treatmant group： （168.25 ± 12.54）/ （112.47 ±6.28）mmHg;diltiazem group： （168.37 ± 1174.16）/（112.49±7.13）mmHg],there was significant reduction in blood pressure in two groups on two weeks and one month af-ter treatment;compared with diltiazem group on two weeks and one month after treatment,there was significant reduction in blood pressure [two weeks：（151.36±6.16）/ （109.17±4.76）mmHg vs.（142.37±2.43）/ （100.43±5.19）mm-Hg,one month：（142.34±6.28）/ （94.16±6.28）mmHg vs.（126.71 ±8.17）/ （87.49±5.37）mmHg]in combined treatment group,P 〈0.01 all.Compared with before treatment [Combined treatmant group：（4.78±2.30）%;diltiazem group：（4.74±2.28）%],there was significant rise in EDD in two groups on two weeks and one month after treatment;compared with diltiazem group on one month after treatment,there was significant rise in EDD [（6.69 ±4.60）% vs. （8.43±4.73）%]in combined treatment group,P 〈0.05 or 〈0.01. Conclusion：Diltiazem combined tanshinone injection can help to improve vascular endothelial function in patients with hypertension.