超声造影对颈动脉粥样硬化斑块新生微血管的评价

Evaluative value of ultrasound contrast for carotid atherosclerotic plaque angiogenesis

目的:探讨超声造影对冠心病颈动脉粥样硬化斑块新生微血管评价的价值。方法:选择冠心病患者62例(CHD组),同期健康体检者62例(健康对照组),均接受超声造影检查,观察两组受检者斑块情况,并比较斑块达峰时间(TTP)、曲线下面积(AUC)、最大峰值强度比(IMAX%)。结果:与健康对照组比较,CHD组软斑(8.06%比56.45%)、硬斑(3.23%比25.81%)、混合斑(1.61%比17.74%)检出率明显提高(P均=0.001),TTP[(22.04±3.41)s比(17.69±3.62)s]明显降低,IM AX%[(50.11±4.12)%比(68.25±6.29)%]和AUC[(1485.62±254.13)Db/s比(2312.15±352.69)Db/s]明显增加(P均=0.001)。超声造影显示CHD组患者颈动脉低回声斑呈弥漫性增强,溃疡斑呈溃疡周边线状增强;健康对照组颈动脉斑块影像无明显增强。结论:超声造影可判断动脉粥样硬化斑块性质,对新生微血管丰富程度进行评估,为临床提供参考。

Objective：To explore evaluative value of ultrasound contrast for carotid atherosclerotic plaque angiogene-sis in patients with coronary heart disease （CHD）.Methods：A total of 62 CHD patients （CHD group）and 62 healthy subjects undergoing physical examination （healthy control group）were selected.Both groups received ultra-sound contrast examination.Plaque condition was observed：its time to peak （TTP）,area under the curve （AUC） and ratio of maximum peak intensity （IMAX%）were compared between two groups.Results：Compared with healthy control group,there were significant rise in detection rates of soft plaque （8.06% vs.56.45%）,hard plaque （3.23% vs.25.81%）and mixed plaque （1.61% vs.17.74%）,P =0.001 all;significant reduction in TTP [（22.04±3.41）s vs.（17.69±3.62）s],and significant rise in IMAX% [（50.11±4.12）% vs.（68.25±6.29）%] and AUC [（1485.62±254.13）Db/s vs.（2312.15±352.69）Db/s]in CHD group,P =0.001 all.Ultrasound con-trast indicated that carotid low echo plaque showed diffuse enhancement and carotid ulcer plaque showed linear en-hancement of ulcer boundary in CHD group,but there was no significant enhancement in carotid plaque image in healthy control group.Conclusion：Ultrasound contrast can determine the nature of atherosclerotic plaques,assess degree of angiogenesis,and provide clinical reference.