丁苯酞联合氟伐他汀对急性脑梗死的疗效评价

Effect of butylphthalide combined with fluvastatin in the treatment of patients with acute cerebral infarction

目的探讨丁苯酞联合氟伐他汀对急性脑梗死(AMI)的疗效及对血液流变学指标的影响。方法选取AMI患者110例,随机分为实验组和对照组各55例,对照组在常规治疗的基础上采用氟伐他汀治疗,实验组在对照组的基础上联合丁苯酞治疗。采用美国国立卫生研究院卒中量表(NIHSS)、Barthel指数评分和精神状态评价量表(MMSE)评价2组治疗后治疗效果;检测并比较2组治疗前后血清C-反应蛋白(CRP)及白介素-6(IL-6)等炎性因子水平的变化及血液流变学指标的变化。结果治疗后2组Barthel指数、MMSE评分显著高于治疗前,NIHSS评分显著低于治疗前,2组差异有统计学意义(P<0.01);治疗后2组CRP、IL-6水平均显著降低,且实验组显著低于对照组(P<0.01);治疗后2组全血高、低切黏度、血浆黏度、红细胞压积及红细胞沉降率均显著降低,且实验组显著低于对照组(P<0.05或P<0.01)。结论丁苯酞联合氟伐他汀可改善AMI患者神经功能障碍和血流变学指标水平,降低血液黏度,从而促进患者神经功能恢复,疗效显著。

Objective To explore the effect of butylphthalide combined with fluvastatin in the treatment of patients with acute cerebral infarction(ACI)and its influence on hemorheology.Methods 110 cases of patients with ACI were selected from April 2015 to November 2016 in our hospital,and randomly divided into experimental group and control group,55 cases in each group.The control group was treated with fluvastatin on the basis of routine treatment,and the experimental group was treated with butylphthalide on the basis of the control group.The effect of the 2groups after treatment were evaluated by National Institutes of Health Stroke Scale(NIHSS),Barthel index score and mental state scale(MMSE);The changes of serum C-reactive protein(CRP),interleukin-6(IL-6)levels and hemorheology indexes were detected and compared between.Results After treatment,Barthel index,MMSE scores of the 2groups were significantly higher than those before treatment,the NIHSS score was significantly lower than that before treatment(P<0.01),and the difference between the 2groups was significant(P<0.01).After treatment,the levels of CRP and IL-6of the 2groups were significantly lower than those before treatment,and the experimental group had significantly lower CRP and IL-6than that of the control group(P<0.01).Compared with that before treatment,whole blood high low shear viscosity,plasma viscosity,hematocrit and erythrocyte sedimentation rate of the 2groups after treatment decreased significantly,and these indexes in the experimental group were significantly lower than that of the control group(P<0.05 or P<0.01).Conclusion Butylphthalide combined with fluvastatin can effectively improve neurologic function and the levels of hemorheology index and reduce blood viscosity in patients with ACI.