百乐眠辅助治疗老年甲亢继发失眠症的疗效观察

Curative Effect Observation of Adjuvant Therapy with Bailemian for the Elderly with Secondary Insomnia after Hyperthyroidism

目的观察百乐眠辅助常规抗甲状腺药物治疗老年甲亢继发失眠症的临床疗效。方法将68例老年甲亢患者随机分成2组,对照组30例给予常规抗甲状腺药物治疗,试验组38例给予常规抗甲状腺药物的同时辅以百乐眠治疗。服药前后检测患者血清FT3、FT4、TT3、TT4、TSH、静息心率,以及匹兹堡睡眠质量指数量表(PSQI)和汉密顿焦虑量表(HAMA)评分,4个疗程后复查,比较2组患者治疗前后上述指标的变化情况。结果治疗后2组患者FT3、FT4、静息心率,以及PSQI和HAMA评分均较治疗前降低,TSH水平升高(P<0.05或P<0.01)。其中试验组较对照组疗效更为显著,差异有统计学意义(P<0.01)。结论百乐眠辅助治疗老年甲状腺机能亢进症可以促进甲状腺功能的恢复,同时有效改善老年甲亢患者的睡眠质量和焦虑程度。

Objective To observe the clinical adjuvant effect of Bailemian in the conventional antithyroid treatmentfor the elderly with secondary insomnia after hyperthyroidism. 8 elderly with hyperthyroidism were randomly di-vided into 2 groups： experiment group（n =38） and control group（n=30）; conventional antithyroid treatment was appliedto the elderly in both groups while the adjuvant therapy with Bailemian was added to the elderly in experiment group; thecourses for both groups lasted for 4 months; before and after treatment, the levels of serum FT3, FT4, TT3, TT4, TSH,resting heart rate of the elderly in the 2 groups were detected and the scores of Pittsburgh sleep quality index （PSQI） andHamilton anxiety scale （HAMA） were collected and recorded, and a comparative study was made to the changes of the indexbetween the2 groups. After treatment, the levels of serum lower than those before treatment while the level of TSHwent up（ P〈0.05 or P〈0.01）, the changes in experiment group was more obvious than those in control group and the differencewas of statistical significance（ P〈0.01）. The adjuvant therapy with Bailemian for the elderly with hyperthyroi-dism can promote the recovery of thyroid function and can effective improve their sleep quality and anxiety.