泛素特异蛋白酶20在乳腺癌组织中的表达及其临床意义

Expression of USP20 in human breast cancer and its significance

目的:通过分析乳腺癌的临床病理特征及观察乳腺癌组织细胞中泛素特异蛋白酶20(ubiquitin-specific proteases20,USP20)的表达情况,探讨二者间的关系及USP20的临床意义。方法:收集经临床病理确诊为浸润性导管癌的乳腺癌组织标本42例,同时选取癌旁相对正常组织作为对照;采用免疫组织化学方法检测USP20在乳腺癌和癌旁组织中的表达情况。结果:42例乳腺癌组织中,27例(64.29%)USP20呈阳性表达,与癌旁组织阳性表达(21.43%)相比显著增加(χ~2=15.75,P<0.01);病理分型中,低分化与高、中分化的总和比较,USP20阳性表达率明显增加(P<0.05);临床分期越晚,USP20阳性表达率越高(χ~2=8.571,P<0.05)。结论:乳腺癌组织中USP20阳性表达与肿瘤分化程度、临床分期有密切关系,提示USP20与乳腺癌恶性程度成正相关,这为临床治疗、预后及进一步研究提供重要的实验依据。

Objective：To observer the relationship between the clinical pathological characteristics of breast cancer and the expression of ubiquitin-specific protease 20 （USP20） to clarify the function of USP20 in breast cancer.Methods：42 specimens invasive ductal carcinoma from breast cancer patients were selected,and 42 specimens from para-cancer tissue were chosen as control.Expression of USP20 was detected with immunohistochemical staining.Results：The positive expression rate of USP20 in breast cancer patients was64.29%,which was higher than that in para-cancer tissue （21.43%）.The difference was significant （χ^2= 15.75,P〈0.01）.Compared with the sum of high and medium differentiation,the positive expression rate of USP20 in low differentiated group was higher （P〈0.05）.Moreover,the later clinical stage,the higher rate was the positive expression of USP20 （χ^2= 8.571,P〈0.05）.Conclusion：The high expression rate of USP20 in human breast cancer is associated with differentiation and clinical stage of the cancer,suggesting that USP20 is positively correlated with the malignancy of breast cancer,which may provide important experimental basis for clinical treatment,prognosis and further research.