不同浓度胺碘酮输注在房颤三维射频消融术后的疗效研究

Effects study of different concentration amiodarone transfusion in atrial fibrillation patients after three-dimensional radiofrequency ablation

目的:评价胺碘酮不同用药浓度在房颤三维射频消融术后短期的有效性。方法:选择62例行三维射频消融术的阵发性心房颤动患者,随机分为高浓度组和低浓度组,每组31例。,高浓度组以胺碘酮12 mg/m L,0.5 mg/min匀速静脉给药,低浓度组以胺碘酮1.2 mg/m L,0.5 mg/min匀速静脉给药,对比不同用药浓度的静脉炎发生率及术后短期预防心房颤动复发的疗效。结果:高浓度给药方式具有更高的静脉炎发生率,但两组对阵发性房颤患者术后72 h内房颤复发差异没有统计学意义。结论:两种用药浓度胺碘酮对三维射频消融术后72 h心房颤动复发预防均有效,低浓度能够减少静脉炎发生。

bObjective：We assessed whether different concentration amiodarone has different short-term effect in atrial fibrillation patients after three-dimensional radiofrequency catheter ablation.Methods：A retrospective analysis of 62 patients with paroxysmal atrial fibrillation accepted three dimensional radiofrequency catheter ablation had been performed.31 patients were administrated amiodarone of 12 mg/m L,and the others had been given amiodarone of 1.2 mg/m L.The incidence of amiodarone-induced phlebitis and shortterm recurrent atrial fibrillation had been analyzed.Results：There was no significant difference in the incidence of recurrent atrial fibrillation in both groups.The incidence of amiodarone-induced phlebitis was higher in high concentration group of peripheral intravenous infusion of amiodarone.Conclusion：It is recommended to apply low concentration of amiodarone so as to reduce the rate of amiodaronerelated phlebitis and have similar effect to prevent recurrent atrial fibrillation after three-dimensional radiofrequency ablation.