中药联合免疫抑制剂在重型再生障碍性贫血中的应用

Application of TCM combined with immunosuppressor in the treatment of SAA

目的:探讨中药联合免疫抑制剂在重型再生障碍性贫血(severe aplastic anemia,SAA)中的应用效果。方法:将31例SAA患者随机分为对照组(n=15)与观察组(n=16)。对照组给予免疫抑制剂治疗,观察组在对照组基础上给予中药方剂治疗。治疗后6个月,观察两组的临床疗效。结果:治疗后,两组外周血液淋巴细胞亚群比例均恢复至正常水平,且观察组恢复程度优于对照组(P<0.05);治疗后,两组血液中的IFN-γmRNA和IL-4 mRNA相对表达量明显降低(P<0.05),且治疗组降低幅度大于对照组(P<0.05);治疗后两组骨髓增生较前活跃,且观察组更为明显。结论:中药联合免疫抑制剂应用于SAA患者的临床效果好,外周血象恢复快,值得临床合理选用。

bObjective：To explore the application efficacy of traditional Chinese medicine （TCM） combined with immunosuppressor in the treatment of severe aplastic anemia （SAA）.Methods：A total of 31 patients with SAA were randomly divided into control group （n = 15） and observation group （n = 16）.Control group was treated with immunosuppressor,on which basis observation group was added with TCM formula.Clinical efficacy was observed in two groups after treatment for 6 months.Results：After treatment,the ratio of peripheral blood lymphocyte subgroups was recovered to normal level in both groups,which was improved more significantly in observation group than that in control group （P〈0.05）.After treatment,the relative expression levels of serum interferon-γ （IFN-γ）mRNA and interleukin-4 （IL-4） mRNA decreased in both groups （P〈0.05）,which decreased more significantly in observation group than that in control group （P〈0.05）.After treatment,bone marrow proliferation was more active in both groups than before,which was more active in observation group.Conclusion：Application of TCM combined with immunosuppressor has better clinical efficacy and fast recovery of peripheral hemogram in the treatment of patients with SAA,thus deserving to be applied properly in clinic.