AMPK信号通路在糖尿病心肌病中的研究进展

Research progress of AMPK pathway in diabetic cardiomyopathy

AMP依赖的蛋白激酶(AMPK)是调节生物能量恒定性的重要传感分子,能激活上游激酶LKB1、Ca MKKβ和Tak1等。AMP/ATP比值可调节AMPK的活性,从而控制能量代谢的分解与合成通路,骨骼肌收缩与心肌缺血时能够激活AMPK,调节脂肪细胞的代谢和血管功能,促进葡萄糖转运和脂肪酸氧化。排除动脉粥样硬化、高血压及其他潜在病因,由糖尿病引发的心肌结构与功能异常的一种独立的原发病,称之为糖尿病心肌病,可引起患者死亡。由于血糖水平、脂肪酸氧化和糖原代谢受AMPK的调节,因此,在DCM形成过程中AMPK起着至关重要的作用。该文综述了AMPK信号通路在糖尿病心肌病发生、发展过程中的作用。

AMP-activated protein kinase （AMPK） is one of the most important sensor molecules which regulates biological ener-gy homeostasis, activating the upstream kinase LKB1 and CaMKK beta and Tak1 and so on. AMP/ATP ratio can modulate AMPK activity, controlling the decomposition and synthesis pathway of energy metabolism, activating AMPK during skeletal muscle contraction and myocardial ischemia, adjusting metabo-lism of fat cells and blood vessel function, promoting glucose transport and fatty acid oxidation. With atherosclerosis, hyper-tension and other potential causes ruled out,diabetic cardiomy-opathy （DCM） is an independent primary disease resulted from abnormal structure and function of myocardium induced by dia-betes, and DCM even brings about death in patients. Due to itsregulation of blood sugar levels,fatty acid oxidation and glyco-gen metabolism,AMPK may play a vital rale in the process of DCM. Based on literature review, this paper summarizes the rale of AMPK pathway in the process of DCM.