换血疗法治疗新生儿高胆红素血症的研究

Effect of Exchange Transfusion Therapy on Neonatal Hyperbilirubinemia

目的研究新生儿高胆红素血症外周动静脉同步换血疗法临床治疗效果。方法用换血疗法治疗高胆红素血症新生儿52例,比较患儿治疗前后血液中总胆红素、直接胆红素、间接胆红素及各项生化指标的差异。结果换血后总胆红素、直接胆红素、间接胆红素均大幅下降,治疗前后比较差异具有统计学意义;Hb含量、血钾、血糖、血钙均升高,治疗前后比较差异具有统计学意义;血钠变化不大,治疗前后比较差异无统计学意义。结论同步换血疗法对新生儿高胆红素血症治疗有非常显著的临床效果。

Objective To study the clinical effect of peripheral arteriovenous synchronous exchange transfusion therapy in neonatal hyperbilirubinemia. Methods 52 neonates with hyperbilirubinemia were collected in our hospital. The differences of total bilirubin,direct bilirubin, indirect bilirubin and biochemical indexes in the blood before and after treatment were compared. Results the level of total bilirubin, direct bilirubin and indirect bilirubin were significantly decreased, with statistically significant difference before and after treatment; the content of Hb, serum potassium, blood glucose, serum calcium was increased, with statistically significant difference before and after treatment; blood sodium changed little, there was no significant difference between before and after treatment.Conclusion synchronous exchange transfusion therapy plays an important role in the treatment of neonatal hyperbilirubinemia.