血清PA与RBP变化在儿童脓毒血症中的临床意义

Clinical Significance of Changes of Serum PA and RBP in Children with Sepsis

目的探讨血清PA与RBP变化在儿童脓毒血症中的临床意义。方法选取70例脓毒血症患儿为A组,非脓毒血症患儿70例为B组,同期体检儿童70例为对照组,对其临床资料进行回顾性分析。采用生化检测分析仪检测各项功能指标情况以及PA和RBP水平,并进行统计学分析。结果总蛋白、总胆红素、直接胆红素、尿素氮、肌酐等指标的组间差异无统计学意义(P>0.05);A组WBC、N、CRP、血糖、谷丙转氨酶、白蛋白等指标与对照组和B组相比差异具有统计学意义(P<0.05);A组PA、RBP水平明显低于对照组和B组,差异具有统计学意义(P<0.05);B组PA、RBP水平与对照组相比,差异无统计学意义(P>0.05)。结论血清PA与RBP是早期肝肾功能损伤的重要因子,血清PA与RBP变化在儿童脓毒血症中的临床意义重大,血清PA与RBP降低有利于脓毒血症的诊断。

Objective To investigate the clinical significance of the changes of serum PA and RBP in children with sepsis.Methods 70 patients with sepsis were selected as group A,70 patients with nonsepsis as B group,and 70 children taken health examination as the control group.The clinical data of the three groups were retrospectively analyzed.Biochemical analysis detector was used for analyzing the changes of multiple functional indicators and levels of PA and RBP.Results There were no significant differences among the three groups in total protein,total bilirubin,direct bilirubin,urea nitrogen and creatinine(P>0.05);the levels of WBC,N,CRP,BS,ALT,and ALB in group A were significantly different from those in the control group and group B(P<0.05);the levels of PA and RBP in group A were significantly lower than those in the control group and group B(P<0.05);there were no significant difference in the levels of RA and RBP between group B and the control group(P>0.05).ConclusionSerum PA and RBP are important factors of early liver and kidney injury.Serum PA and RBP have great clinical significance in children with sepsis,and the decrease of serum PA and RBP is helpful to the diagnosis of sepsis.